β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive

Young Jae Moon; Sun Jung Yoon; Jeung Hyun Koo; Yihyun Yoon; Hye Jun Byun; Hyeon Soo Kim; Gilson Khang; Heung Jae Chun; Dae Hyeok Yang

doi:10.3390/ijms22020700

β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive

Young Jae Moon
, Sun Jung Yoon
, Jeung Hyun Koo
, Yihyun Yoon
, Hye Jun Byun
, Hyeon Soo Kim
, Gilson Khang
, Heung Jae Chun
, Dae Hyeok Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

13 Scopus citations

Abstract

Accelerating wound healing with minimized bacterial infection has become a topic of interest in the development of the new generation of tissue bio-adhesives. In this study, we fabricated a hydrogel system (MGC-g-CD-ic-TCS) consisting of triclosan (TCS)-complexed beta-cyclodextrin (β-CD)-conjugated methacrylated glycol chitosan (MGC) as an antibacterial tissue adhesive. Proton nuclear magnetic resonance (¹H NMR) and differential scanning calorimetry (DSC) results showed the inclusion complex formation between MGC-g-CD and TCS. The increase of storage modulus (G’) of MGC-g-CD-ic-TCS after visible light irradiation for 200 s indicated its hydrogelation. The swollen hydrogel in aqueous solution resulted in two release behaviors of an initial burst and sustained release. Importantly, in vitro and in vivo results indicated that MGC-g-CD-ic-TCS inhibited bacterial infection and improved wound healing, suggesting its high potential application as an antibacterial tissue bio-adhesive.

Original language	English
Article number	700
Pages (from-to)	1-18
Number of pages	18
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	2
DOIs	https://doi.org/10.3390/ijms22020700
State	Published - 2021.01.2

Keywords

Antibacterial
Beta-cyclodextrin
Methacrylate glycol chitosan
Tissue bio-adhesive
Triclosan

Quacquarelli Symonds(QS) Subject Topics

Computer Science & Information Systems
Engineering - Petroleum
Data Science
Engineering - Chemical
Chemistry
Biological Sciences

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10.3390/ijms22020700

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Moon, Y. J., Yoon, S. J., Koo, J. H., Yoon, Y., Byun, H. J., Kim, H. S., Khang, G., Chun, H. J., & Yang, D. H. (2021). β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive. International Journal of Molecular Sciences, 22(2), 1-18. Article 700. https://doi.org/10.3390/ijms22020700

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title = "β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive",

abstract = "Accelerating wound healing with minimized bacterial infection has become a topic of interest in the development of the new generation of tissue bio-adhesives. In this study, we fabricated a hydrogel system (MGC-g-CD-ic-TCS) consisting of triclosan (TCS)-complexed beta-cyclodextrin (β-CD)-conjugated methacrylated glycol chitosan (MGC) as an antibacterial tissue adhesive. Proton nuclear magnetic resonance (1H NMR) and differential scanning calorimetry (DSC) results showed the inclusion complex formation between MGC-g-CD and TCS. The increase of storage modulus (G{\textquoteright}) of MGC-g-CD-ic-TCS after visible light irradiation for 200 s indicated its hydrogelation. The swollen hydrogel in aqueous solution resulted in two release behaviors of an initial burst and sustained release. Importantly, in vitro and in vivo results indicated that MGC-g-CD-ic-TCS inhibited bacterial infection and improved wound healing, suggesting its high potential application as an antibacterial tissue bio-adhesive.",

keywords = "Antibacterial, Beta-cyclodextrin, Methacrylate glycol chitosan, Tissue bio-adhesive, Triclosan",

author = "Moon, \{Young Jae\} and Yoon, \{Sun Jung\} and Koo, \{Jeung Hyun\} and Yihyun Yoon and Byun, \{Hye Jun\} and Kim, \{Hyeon Soo\} and Gilson Khang and Chun, \{Heung Jae\} and Yang, \{Dae Hyeok\}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jan,

day = "2",

doi = "10.3390/ijms22020700",

language = "English",

volume = "22",

pages = "1--18",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

number = "2",

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β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive. / Moon, Young Jae ; Yoon, Sun Jung; Koo, Jeung Hyun et al.
In: International Journal of Molecular Sciences, Vol. 22, No. 2, 700, 02.01.2021, p. 1-18.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive

AU - Moon, Young Jae

AU - Yoon, Sun Jung

AU - Koo, Jeung Hyun

AU - Yoon, Yihyun

AU - Byun, Hye Jun

AU - Kim, Hyeon Soo

AU - Khang, Gilson

AU - Chun, Heung Jae

AU - Yang, Dae Hyeok

PY - 2021/1/2

Y1 - 2021/1/2

N2 - Accelerating wound healing with minimized bacterial infection has become a topic of interest in the development of the new generation of tissue bio-adhesives. In this study, we fabricated a hydrogel system (MGC-g-CD-ic-TCS) consisting of triclosan (TCS)-complexed beta-cyclodextrin (β-CD)-conjugated methacrylated glycol chitosan (MGC) as an antibacterial tissue adhesive. Proton nuclear magnetic resonance (1H NMR) and differential scanning calorimetry (DSC) results showed the inclusion complex formation between MGC-g-CD and TCS. The increase of storage modulus (G’) of MGC-g-CD-ic-TCS after visible light irradiation for 200 s indicated its hydrogelation. The swollen hydrogel in aqueous solution resulted in two release behaviors of an initial burst and sustained release. Importantly, in vitro and in vivo results indicated that MGC-g-CD-ic-TCS inhibited bacterial infection and improved wound healing, suggesting its high potential application as an antibacterial tissue bio-adhesive.

AB - Accelerating wound healing with minimized bacterial infection has become a topic of interest in the development of the new generation of tissue bio-adhesives. In this study, we fabricated a hydrogel system (MGC-g-CD-ic-TCS) consisting of triclosan (TCS)-complexed beta-cyclodextrin (β-CD)-conjugated methacrylated glycol chitosan (MGC) as an antibacterial tissue adhesive. Proton nuclear magnetic resonance (1H NMR) and differential scanning calorimetry (DSC) results showed the inclusion complex formation between MGC-g-CD and TCS. The increase of storage modulus (G’) of MGC-g-CD-ic-TCS after visible light irradiation for 200 s indicated its hydrogelation. The swollen hydrogel in aqueous solution resulted in two release behaviors of an initial burst and sustained release. Importantly, in vitro and in vivo results indicated that MGC-g-CD-ic-TCS inhibited bacterial infection and improved wound healing, suggesting its high potential application as an antibacterial tissue bio-adhesive.

KW - Antibacterial

KW - Beta-cyclodextrin

KW - Methacrylate glycol chitosan

KW - Tissue bio-adhesive

KW - Triclosan

UR - https://www.scopus.com/pages/publications/85099417905

U2 - 10.3390/ijms22020700

DO - 10.3390/ijms22020700

M3 - Journal article

C2 - 33445775

AN - SCOPUS:85099417905

SN - 1661-6596

VL - 22

SP - 1

EP - 18

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 2

M1 - 700

ER -

β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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