덱시부프로펜 자당-고분자 섬유 매트릭스와 매트릭스 효과

Poorly soluble drugs have lower bioavailability and patient compliance than highly soluble drugs. Therefore, problems such as overdose and side effects have been reported. Dexibuprofen (DP), which is a poorly soluble drug, has been used as a representative analgesic and anti-inflammatory agent. It is reported that there is a limitation in absorption in the human body after administration. DP was selected as a model, and the objective was to improve bioavailability and patient compliance by fabricating a fibrous matrix. We expected a reduction of side effects and the enhancement of therapeutic effects by mixing vitamin C (VC) with dexibuprofen. After improving the flowability and compositional uniformity of the mixture by applying the wet granulation (WG) process, a sucrose-based fibrous matrix was fabricated using the centrifugal melt-spinning process. These were composed as Batch (BAT) 1–3 depending on the presence and type of polymer binder. In this study, we fabricated a fibrous matrix composed of sucrose, polymer, dexibuprofen, and vitamin C through the centrifugal melt-spinning process, and assessed the structural changes and matrix effects in the process.