Abstract
This study proposes a Hot Melt Extrusion method-based solid dispersion using HPMC to improve the solubility and achieve sustained release of rebamipide. The rebamipide solid dispersions show a 19-fold increase in water solubility compared with the pure rebamipide by combining pH adjustment and various surfactants. Fourier transform infrared spectroscopy (FTIR), X-ray diffractometer (XRD), and differential scanning calorimetry (DSC) analyses confirmed the amorphous transformation of rebamipide and its stable dispersion in the polymer matrix. Sustained-release tablet, prepared with rebamipide solid dispersion, showed first-order dissolution pattern over 14 hours, consistently with a diffusion-controlled mechanism. As a result, this study demonstrates the potential of combining solid dispersion and sustained-release technologies based on hot-melt extrusion method as an effective formulation platform for simultaneous solubility enhancement and controlled drug release.
| Translated title of the contribution | Formulation Study of HPMC-based Hot-melt Extruded Rebamipide SolidDispersions for Solubility Enhancement and Sustained Release |
|---|---|
| Original language | Korean |
| Pages (from-to) | 348-355 |
| Number of pages | 8 |
| Journal | Polymer (Korea) |
| Volume | 50 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2026.03 |
Keywords
- hot-melt extrusion
- rebamipide
- solid dispersion
- solubilization
- sustained release
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