9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic produced by Micromonospora sp. SA246

Woon Hyung Yeo; Bong Sik Yun; Nam In Back; Young Ho Kim; Sang Seock Kim; Eun Kyung Park; Kyung Sook Whang; Seung Hun Yu

doi:10.7164/antibiotics.50.546

9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic produced by Micromonospora sp. SA246

Woon Hyung Yeo
, Bong Sik Yun
, Nam In Back
, Young Ho Kim
, Sang Seock Kim
, Eun Kyung Park
, Kyung Sook Whang
, Seung Hun Yu^*

^*Corresponding author for this work

Environmental Biotechnology

Yusong, 305-345
Korea Institute of Science and Technology
Kyung Hee University
Mokwon University
Chungnam National University

Research output: Contribution to journal › Journal article › peer-review

13 Scopus citations

Abstract

9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic, was isolated from a soil microorganism SA246 which was identified as Micromonospora sp. The molecular formula of 9-hydroxycrisamicin A was determined as C₃₂H₂₂O₁₃ based on the HRFAB-MS analysis, and the structure was determined by various NMR experiments. 9-Hydroxycrisamicin A showed weak antimicrobial activity against Gram-positive bacteria acid strong cytotoxic activity against some human cancer cell lines such as SK-OV-3 (ovarian), HCT15 (colon), SK-MEL-2 (melanoma), A549 (lung), XF498 (central nervous system) with ED₅₀ of 0.47 ~ 0.65 μg/ml.

Original language	English
Pages (from-to)	546-550
Number of pages	5
Journal	Journal of Antibiotics
Volume	50
Issue number	7
DOIs	https://doi.org/10.7164/antibiotics.50.546
State	Published - 1997.07

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title = "9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic produced by Micromonospora sp. SA246",

abstract = "9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic, was isolated from a soil microorganism SA246 which was identified as Micromonospora sp. The molecular formula of 9-hydroxycrisamicin A was determined as C32H22O13 based on the HRFAB-MS analysis, and the structure was determined by various NMR experiments. 9-Hydroxycrisamicin A showed weak antimicrobial activity against Gram-positive bacteria acid strong cytotoxic activity against some human cancer cell lines such as SK-OV-3 (ovarian), HCT15 (colon), SK-MEL-2 (melanoma), A549 (lung), XF498 (central nervous system) with ED50 of 0.47 \textasciitilde{} 0.65 μg/ml.",

author = "Yeo, \{Woon Hyung\} and Yun, \{Bong Sik\} and Back, \{Nam In\} and Kim, \{Young Ho\} and Kim, \{Sang Seock\} and Park, \{Eun Kyung\} and Whang, \{Kyung Sook\} and Yu, \{Seung Hun\}",

year = "1997",

month = jul,

doi = "10.7164/antibiotics.50.546",

language = "English",

volume = "50",

pages = "546--550",

journal = "Journal of Antibiotics",

issn = "0021-8820",

number = "7",

}

TY - JOUR

T1 - 9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic produced by Micromonospora sp. SA246

AU - Yeo, Woon Hyung

AU - Yun, Bong Sik

AU - Back, Nam In

AU - Kim, Young Ho

AU - Kim, Sang Seock

AU - Park, Eun Kyung

AU - Whang, Kyung Sook

AU - Yu, Seung Hun

PY - 1997/7

Y1 - 1997/7

N2 - 9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic, was isolated from a soil microorganism SA246 which was identified as Micromonospora sp. The molecular formula of 9-hydroxycrisamicin A was determined as C32H22O13 based on the HRFAB-MS analysis, and the structure was determined by various NMR experiments. 9-Hydroxycrisamicin A showed weak antimicrobial activity against Gram-positive bacteria acid strong cytotoxic activity against some human cancer cell lines such as SK-OV-3 (ovarian), HCT15 (colon), SK-MEL-2 (melanoma), A549 (lung), XF498 (central nervous system) with ED50 of 0.47 ~ 0.65 μg/ml.

AB - 9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic, was isolated from a soil microorganism SA246 which was identified as Micromonospora sp. The molecular formula of 9-hydroxycrisamicin A was determined as C32H22O13 based on the HRFAB-MS analysis, and the structure was determined by various NMR experiments. 9-Hydroxycrisamicin A showed weak antimicrobial activity against Gram-positive bacteria acid strong cytotoxic activity against some human cancer cell lines such as SK-OV-3 (ovarian), HCT15 (colon), SK-MEL-2 (melanoma), A549 (lung), XF498 (central nervous system) with ED50 of 0.47 ~ 0.65 μg/ml.

UR - https://www.scopus.com/pages/publications/0030806549

U2 - 10.7164/antibiotics.50.546

DO - 10.7164/antibiotics.50.546

M3 - Journal article

C2 - 9711245

AN - SCOPUS:0030806549

SN - 0021-8820

VL - 50

SP - 546

EP - 550

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 7

ER -

9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic produced by Micromonospora sp. SA246

Abstract

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