A calcium-calmodulin antagonist blocks experimental Vibrio vulnificus cytolysin-induced lethality in an experimental mouse model

Young Rae Lee; Kwang Hyun Park; Zhao Zhen Lin; Young Jong Kho; Jin Woo Park; Hye Won Rho; Bon Sun Koo; Hyung Rho Kim; Eun Kyung Song; Hong Nu Yu; Myung Kwan Han; Seung Ok Lee; Eun Chung Jhee; Jong Suk Kim

doi:10.1128/IAI.72.10.6157-6159.2004

A calcium-calmodulin antagonist blocks experimental Vibrio vulnificus cytolysin-induced lethality in an experimental mouse model

Young Rae Lee
, Kwang Hyun Park
, Zhao Zhen Lin
, Young Jong Kho
, Jin Woo Park
, Hye Won Rho
, Bon Sun Koo
, Hyung Rho Kim
, Eun Kyung Song
, Hong Nu Yu
, Myung Kwan Han
, Seung Ok Lee
, Eun Chung Jhee
, Jong Suk Kim^*

^*Corresponding author for this work

Department of Medicine

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

11 Scopus citations

Abstract

We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.

Original language	English
Pages (from-to)	6157-6159
Number of pages	3
Journal	Infection and Immunity
Volume	72
Issue number	10
DOIs	https://doi.org/10.1128/IAI.72.10.6157-6159.2004
State	Published - 2004.10

Quacquarelli Symonds(QS) Subject Topics

Medicine
Biological Sciences

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10.1128/IAI.72.10.6157-6159.2004

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Lee, Y. R., Park, K. H., Lin, Z. Z., Kho, Y. J., Park, J. W., Rho, H. W., Koo, B. S., Kim, H. R., Song, E. K., Yu, H. N., Han, M. K., Lee, S. O., Jhee, E. C., & Kim, J. S. (2004). A calcium-calmodulin antagonist blocks experimental Vibrio vulnificus cytolysin-induced lethality in an experimental mouse model. Infection and Immunity, 72(10), 6157-6159. https://doi.org/10.1128/IAI.72.10.6157-6159.2004

@article{cbc1f8e14b33412fb2a79d4829dc13c8,

title = "A calcium-calmodulin antagonist blocks experimental Vibrio vulnificus cytolysin-induced lethality in an experimental mouse model",

abstract = "We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.",

author = "Lee, \{Young Rae\} and Park, \{Kwang Hyun\} and Lin, \{Zhao Zhen\} and Kho, \{Young Jong\} and Park, \{Jin Woo\} and Rho, \{Hye Won\} and Koo, \{Bon Sun\} and Kim, \{Hyung Rho\} and Song, \{Eun Kyung\} and Yu, \{Hong Nu\} and Han, \{Myung Kwan\} and Lee, \{Seung Ok\} and Jhee, \{Eun Chung\} and Kim, \{Jong Suk\}",

year = "2004",

month = oct,

doi = "10.1128/IAI.72.10.6157-6159.2004",

language = "English",

volume = "72",

pages = "6157--6159",

journal = "Infection and Immunity",

issn = "0019-9567",

number = "10",

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Lee, YR, Park, KH, Lin, ZZ, Kho, YJ, Park, JW, Rho, HW, Koo, BS, Kim, HR, Song, EK, Yu, HN, Han, MK , Lee, SO, Jhee, EC & Kim, JS 2004, 'A calcium-calmodulin antagonist blocks experimental Vibrio vulnificus cytolysin-induced lethality in an experimental mouse model', Infection and Immunity, vol. 72, no. 10, pp. 6157-6159. https://doi.org/10.1128/IAI.72.10.6157-6159.2004

TY - JOUR

T1 - A calcium-calmodulin antagonist blocks experimental Vibrio vulnificus cytolysin-induced lethality in an experimental mouse model

AU - Lee, Young Rae

AU - Park, Kwang Hyun

AU - Lin, Zhao Zhen

AU - Kho, Young Jong

AU - Park, Jin Woo

AU - Rho, Hye Won

AU - Koo, Bon Sun

AU - Kim, Hyung Rho

AU - Song, Eun Kyung

AU - Yu, Hong Nu

AU - Han, Myung Kwan

AU - Lee, Seung Ok

AU - Jhee, Eun Chung

AU - Kim, Jong Suk

PY - 2004/10

Y1 - 2004/10

N2 - We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.

AB - We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.

UR - https://www.scopus.com/pages/publications/4644300375

U2 - 10.1128/IAI.72.10.6157-6159.2004

DO - 10.1128/IAI.72.10.6157-6159.2004

M3 - Journal article

C2 - 15385523

AN - SCOPUS:4644300375

SN - 0019-9567

VL - 72

SP - 6157

EP - 6159

JO - Infection and Immunity

JF - Infection and Immunity

IS - 10

ER -

A calcium-calmodulin antagonist blocks experimental Vibrio vulnificus cytolysin-induced lethality in an experimental mouse model

Abstract

Quacquarelli Symonds(QS) Subject Topics

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