Abstract
No previous study examined a disease modifying effect of APOE E4 status on the association between the urinary albumin-to-creatinine ratio (UACR) and cognition.
We performed a cross-sectional study in adults aged 45 to 74 who were living in Namwon City, Republic of Korea.
A total of 10,190 participants (4006 men and 6184 women) were analyzed in the present study. Of these, 1698 subjects (16.7%) were APOE E4 carriers. The UACR values were negatively associated with the K-mMMSE scores, even after adjusting for potential confounders including age, sex, education, and vascular risk factors. APOE E4 modified the association significantly, resulting in a steeper decline of cognitive function with the increase in UACR in E4 carriers (P for interaction = 0.021)
Higher UACR values were significantly associated with cognitive dysfunction in the general Korean population, with cognition in APOE E4 carriers being more severely affected by increased UACR.
| Original language | English |
|---|---|
| Article number | 724281 |
| Journal | Disease Markers |
| Volume | 2014 |
| DOIs | |
| State | Published - 2014 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being -
SDG 5 Gender Equality
Quacquarelli Symonds(QS) Subject Topics
- Medicine
- Biological Sciences
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