Abstract
A facile synthetic method for the preparation of unsymmetrical ureas from amines is described. Carbamoyl imidazole compounds were prepared by the reaction of 1, 1-carbonyldiimidazole with primary or secondary amines, and further activation by treatment with zirconium(IV) chloride to generate the desired urea. This reaction protocol was applied to the synthesis of tri and tetrasubstituted ureas with high yields. This study provides an alternative guideline for the practical preparation of various unsymmetrical ureas.
| Original language | English |
|---|---|
| Pages (from-to) | 154-160 |
| Number of pages | 7 |
| Journal | Bulletin of the Korean Chemical Society |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2016.02.1 |
Keywords
- Carbamoyl imidazole
- Unsymmetrical urea
- Zirconium(IV) chloride
Quacquarelli Symonds(QS) Subject Topics
- Chemistry
Fingerprint
Dive into the research topics of 'A facile method for the preparation of unsymmetrical ureas utilizing zirconium (IV) chloride'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver