A new antioxidant clitocybin A, from the culture broth of Clitocybe aurantiaca

Young Hee Kim; Sung Min Cho; Jin Won Hyun; In Ja Ryoo; Soo Jin Choo; Sangku Lee; Soon Ja Seok; Jae Sung Hwang; Eui Dong Sohn; Bong Sik Yun; Ki Hwan Bae; Ick Dong Yoo

doi:10.1038/ja.2008.77

A new antioxidant clitocybin A, from the culture broth of Clitocybe aurantiaca

Young Hee Kim
, Sung Min Cho
, Jin Won Hyun
, In Ja Ryoo
, Soo Jin Choo
, Sangku Lee
, Soon Ja Seok
, Jae Sung Hwang
, Eui Dong Sohn
, Bong Sik Yun
, Ki Hwan Bae
, Ick Dong Yoo^*

^*Corresponding author for this work

Environmental Biotechnology

Korea Research Institute of Bioscience and Biotechnology
Jeju National University
United States Food and Drug Administration
Amorepacific Corporation
Chungnam National University

Research output: Contribution to journal › Journal article › peer-review

18 Scopus citations

Abstract

Clitocybin A (1), a new antioxidant, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC. Its structure was determined as 4,6-dihydroxy-2-ρ-hydroxyphenyl- isoindol-1-one on the basis of the UV, NMR, and MS spectroscopic analysis. The compound 1 showed potent free radical scavenging activity against superoxide, ABTS, and DPPH radicals, and protective effect against cellular DNA damage induced by oxidative stress.

Original language	English
Pages (from-to)	573-576
Number of pages	4
Journal	Journal of Antibiotics
Volume	61
Issue number	9
DOIs	https://doi.org/10.1038/ja.2008.77
State	Published - 2008.09

Keywords

Antioxidant activity
Clitocybe aurantiaca
Clitocybin A
Comet assay

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10.1038/ja.2008.77

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title = "A new antioxidant clitocybin A, from the culture broth of Clitocybe aurantiaca",

abstract = "Clitocybin A (1), a new antioxidant, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC. Its structure was determined as 4,6-dihydroxy-2-ρ-hydroxyphenyl- isoindol-1-one on the basis of the UV, NMR, and MS spectroscopic analysis. The compound 1 showed potent free radical scavenging activity against superoxide, ABTS, and DPPH radicals, and protective effect against cellular DNA damage induced by oxidative stress.",

keywords = "Antioxidant activity, Clitocybe aurantiaca, Clitocybin A, Comet assay",

author = "Kim, \{Young Hee\} and Cho, \{Sung Min\} and Hyun, \{Jin Won\} and Ryoo, \{In Ja\} and Choo, \{Soo Jin\} and Sangku Lee and Seok, \{Soon Ja\} and Hwang, \{Jae Sung\} and Sohn, \{Eui Dong\} and Yun, \{Bong Sik\} and Bae, \{Ki Hwan\} and Yoo, \{Ick Dong\}",

year = "2008",

month = sep,

doi = "10.1038/ja.2008.77",

language = "English",

volume = "61",

pages = "573--576",

journal = "Journal of Antibiotics",

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T1 - A new antioxidant clitocybin A, from the culture broth of Clitocybe aurantiaca

AU - Kim, Young Hee

AU - Cho, Sung Min

AU - Hyun, Jin Won

AU - Ryoo, In Ja

AU - Choo, Soo Jin

AU - Lee, Sangku

AU - Seok, Soon Ja

AU - Hwang, Jae Sung

AU - Sohn, Eui Dong

AU - Yun, Bong Sik

AU - Bae, Ki Hwan

AU - Yoo, Ick Dong

PY - 2008/9

Y1 - 2008/9

N2 - Clitocybin A (1), a new antioxidant, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC. Its structure was determined as 4,6-dihydroxy-2-ρ-hydroxyphenyl- isoindol-1-one on the basis of the UV, NMR, and MS spectroscopic analysis. The compound 1 showed potent free radical scavenging activity against superoxide, ABTS, and DPPH radicals, and protective effect against cellular DNA damage induced by oxidative stress.

AB - Clitocybin A (1), a new antioxidant, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC. Its structure was determined as 4,6-dihydroxy-2-ρ-hydroxyphenyl- isoindol-1-one on the basis of the UV, NMR, and MS spectroscopic analysis. The compound 1 showed potent free radical scavenging activity against superoxide, ABTS, and DPPH radicals, and protective effect against cellular DNA damage induced by oxidative stress.

KW - Antioxidant activity

KW - Clitocybe aurantiaca

KW - Clitocybin A

KW - Comet assay

UR - https://www.scopus.com/pages/publications/57849091859

U2 - 10.1038/ja.2008.77

DO - 10.1038/ja.2008.77

M3 - Journal article

C2 - 19160526

AN - SCOPUS:57849091859

SN - 0021-8820

VL - 61

SP - 573

EP - 576

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 9

ER -

A new antioxidant clitocybin A, from the culture broth of Clitocybe aurantiaca

Abstract

Keywords

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