A new neo-lignan from culture broth of Phellinus linteus and its dengue virus type-2 inhibition activity

Young Hee Kim; Dae Cheol Choi; Dae Won Ki; Ji Yul Kim; Jae Hyoung Song; Hyun Jeong Ko; In Kyoung Lee; Bong Sik Yun

doi:10.1016/j.phytol.2024.08.005

A new neo-lignan from culture broth of Phellinus linteus and its dengue virus type-2 inhibition activity

Young Hee Kim
, Dae Cheol Choi
, Dae Won Ki
, Ji Yul Kim
, Jae Hyoung Song
, Hyun Jeong Ko
, In Kyoung Lee^*
, Bong Sik Yun

^*Corresponding author for this work

Environmental Biotechnology

Jeonbuk National University
National Marine Biodiversity Institute of Korea
Kangwon National University

Research output: Contribution to journal › Journal article › peer-review

1 Scopus citations

Abstract

Several species within the genus Phellinus are used as a traditional medicine for various health conditions. A new neo-lignan derivative, phelignan A (1), and a known neo-lignan (2) were isolated from the culture broth of P. linteus. The chemical structures of the isolated compounds were determined using 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The anti-viral activity of the isolated compounds against dengue virus-2 (DENV-2) was evaluated. Compounds 1 and 2 exhibited anti-viral activity against DENV-2, with IC₅₀ values of 1.45 and 2.15 µM, respectively.

Original language	English
Pages (from-to)	43-46
Number of pages	4
Journal	Phytochemistry Letters
Volume	63
DOIs	https://doi.org/10.1016/j.phytol.2024.08.005
State	Published - 2024.10

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Dengue virus type-2 inhibition
Hymenochaetaceae
Neo-lignan
Phellinus linteus

Quacquarelli Symonds(QS) Subject Topics

Agriculture & Forestry
Biological Sciences

Access to Document

10.1016/j.phytol.2024.08.005

Cite this

@article{4ff3a682ca664d1abf83611a544edf12,

title = "A new neo-lignan from culture broth of Phellinus linteus and its dengue virus type-2 inhibition activity",

abstract = "Several species within the genus Phellinus are used as a traditional medicine for various health conditions. A new neo-lignan derivative, phelignan A (1), and a known neo-lignan (2) were isolated from the culture broth of P. linteus. The chemical structures of the isolated compounds were determined using 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The anti-viral activity of the isolated compounds against dengue virus-2 (DENV-2) was evaluated. Compounds 1 and 2 exhibited anti-viral activity against DENV-2, with IC50 values of 1.45 and 2.15 µM, respectively.",

keywords = "Dengue virus type-2 inhibition, Hymenochaetaceae, Neo-lignan, Phellinus linteus",

author = "Kim, \{Young Hee\} and Choi, \{Dae Cheol\} and Ki, \{Dae Won\} and Kim, \{Ji Yul\} and Song, \{Jae Hyoung\} and Ko, \{Hyun Jeong\} and Lee, \{In Kyoung\} and Yun, \{Bong Sik\}",

note = "Publisher Copyright: {\textcopyright} 2024 Phytochemical Society of Europe",

year = "2024",

month = oct,

doi = "10.1016/j.phytol.2024.08.005",

language = "English",

volume = "63",

pages = "43--46",

journal = "Phytochemistry Letters",

issn = "1874-3900",

}

TY - JOUR

T1 - A new neo-lignan from culture broth of Phellinus linteus and its dengue virus type-2 inhibition activity

AU - Kim, Young Hee

AU - Choi, Dae Cheol

AU - Ki, Dae Won

AU - Kim, Ji Yul

AU - Song, Jae Hyoung

AU - Ko, Hyun Jeong

AU - Lee, In Kyoung

AU - Yun, Bong Sik

PY - 2024/10

Y1 - 2024/10

N2 - Several species within the genus Phellinus are used as a traditional medicine for various health conditions. A new neo-lignan derivative, phelignan A (1), and a known neo-lignan (2) were isolated from the culture broth of P. linteus. The chemical structures of the isolated compounds were determined using 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The anti-viral activity of the isolated compounds against dengue virus-2 (DENV-2) was evaluated. Compounds 1 and 2 exhibited anti-viral activity against DENV-2, with IC50 values of 1.45 and 2.15 µM, respectively.

AB - Several species within the genus Phellinus are used as a traditional medicine for various health conditions. A new neo-lignan derivative, phelignan A (1), and a known neo-lignan (2) were isolated from the culture broth of P. linteus. The chemical structures of the isolated compounds were determined using 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The anti-viral activity of the isolated compounds against dengue virus-2 (DENV-2) was evaluated. Compounds 1 and 2 exhibited anti-viral activity against DENV-2, with IC50 values of 1.45 and 2.15 µM, respectively.

KW - Dengue virus type-2 inhibition

KW - Hymenochaetaceae

KW - Neo-lignan

KW - Phellinus linteus

UR - https://www.scopus.com/pages/publications/85200783993

U2 - 10.1016/j.phytol.2024.08.005

DO - 10.1016/j.phytol.2024.08.005

M3 - Journal article

AN - SCOPUS:85200783993

SN - 1874-3900

VL - 63

SP - 43

EP - 46

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

A new neo-lignan from culture broth of Phellinus linteus and its dengue virus type-2 inhibition activity

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

Other files and links

Fingerprint

Cite this