A new sesquiterpenoid with antibacterial activity from the leaves of Rosa rugosa

Soo Jeong Lee; Dae Cheol Choi; Seok Chun Ko; Mi Jin Yim; Gun Woo Oh; Dongwoo Yang; Dae Sung Lee; Jeong Min Lee; Bong Sik Yun; Ji Yul Kim

doi:10.1016/j.phytol.2026.104217

A new sesquiterpenoid with antibacterial activity from the leaves of Rosa rugosa

Soo Jeong Lee
, Dae Cheol Choi
, Seok Chun Ko
, Mi Jin Yim
, Gun Woo Oh
, Dongwoo Yang
, Dae Sung Lee
, Jeong Min Lee
, Bong Sik Yun^*
, Ji Yul Kim^*

^*Corresponding author for this work

Environmental Biotechnology

Jeonbuk National University
National Marine Biodiversity Institute of Korea

Research output: Contribution to journal › Journal article › peer-review

Abstract

A new sesquiterpenoid, rugosic acid E (1), along with three known secondary metabolites (2-4) were isolated from the chloroform-soluble layer fraction of the leaves of Rosa rugosa using diverse chromatographic techniques. The planar structures were elucidated by NMR and HRESIMS spectroscopic methods. Furthermore, the absolute configuration of rugosic acid E (1) was determined by comparison of ECD calculations. All the compounds were evaluated for antibacterial activity against two Gram-positive bacteria, Bacillus subtilis and Bacillus cereus. Only compounds 1 and 2 exhibited weak antibacterial activity at a concentration of 400 μg per disk.

Original language	English
Article number	104217
Journal	Phytochemistry Letters
Volume	75
DOIs	https://doi.org/10.1016/j.phytol.2026.104217
State	Published - 2026.10

Keywords

Antibacterial activity
Rosa rugosa
Rosaceae
Sesquiterpenoid
Structure elucidation

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10.1016/j.phytol.2026.104217

Cite this

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title = "A new sesquiterpenoid with antibacterial activity from the leaves of Rosa rugosa",

abstract = "A new sesquiterpenoid, rugosic acid E (1), along with three known secondary metabolites (2-4) were isolated from the chloroform-soluble layer fraction of the leaves of Rosa rugosa using diverse chromatographic techniques. The planar structures were elucidated by NMR and HRESIMS spectroscopic methods. Furthermore, the absolute configuration of rugosic acid E (1) was determined by comparison of ECD calculations. All the compounds were evaluated for antibacterial activity against two Gram-positive bacteria, Bacillus subtilis and Bacillus cereus. Only compounds 1 and 2 exhibited weak antibacterial activity at a concentration of 400 μg per disk.",

keywords = "Antibacterial activity, Rosa rugosa, Rosaceae, Sesquiterpenoid, Structure elucidation",

author = "Lee, \{Soo Jeong\} and Choi, \{Dae Cheol\} and Ko, \{Seok Chun\} and Yim, \{Mi Jin\} and Oh, \{Gun Woo\} and Dongwoo Yang and Lee, \{Dae Sung\} and Lee, \{Jeong Min\} and Yun, \{Bong Sik\} and Kim, \{Ji Yul\}",

note = "Publisher Copyright: {\textcopyright} 2026 Phytochemical Society of Europe",

year = "2026",

month = oct,

doi = "10.1016/j.phytol.2026.104217",

language = "English",

volume = "75",

journal = "Phytochemistry Letters",

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T1 - A new sesquiterpenoid with antibacterial activity from the leaves of Rosa rugosa

AU - Lee, Soo Jeong

AU - Choi, Dae Cheol

AU - Ko, Seok Chun

AU - Yim, Mi Jin

AU - Oh, Gun Woo

AU - Yang, Dongwoo

AU - Lee, Dae Sung

AU - Lee, Jeong Min

AU - Yun, Bong Sik

AU - Kim, Ji Yul

PY - 2026/10

Y1 - 2026/10

N2 - A new sesquiterpenoid, rugosic acid E (1), along with three known secondary metabolites (2-4) were isolated from the chloroform-soluble layer fraction of the leaves of Rosa rugosa using diverse chromatographic techniques. The planar structures were elucidated by NMR and HRESIMS spectroscopic methods. Furthermore, the absolute configuration of rugosic acid E (1) was determined by comparison of ECD calculations. All the compounds were evaluated for antibacterial activity against two Gram-positive bacteria, Bacillus subtilis and Bacillus cereus. Only compounds 1 and 2 exhibited weak antibacterial activity at a concentration of 400 μg per disk.

AB - A new sesquiterpenoid, rugosic acid E (1), along with three known secondary metabolites (2-4) were isolated from the chloroform-soluble layer fraction of the leaves of Rosa rugosa using diverse chromatographic techniques. The planar structures were elucidated by NMR and HRESIMS spectroscopic methods. Furthermore, the absolute configuration of rugosic acid E (1) was determined by comparison of ECD calculations. All the compounds were evaluated for antibacterial activity against two Gram-positive bacteria, Bacillus subtilis and Bacillus cereus. Only compounds 1 and 2 exhibited weak antibacterial activity at a concentration of 400 μg per disk.

KW - Antibacterial activity

KW - Rosa rugosa

KW - Rosaceae

KW - Sesquiterpenoid

KW - Structure elucidation

UR - https://www.scopus.com/pages/publications/105045322335

U2 - 10.1016/j.phytol.2026.104217

DO - 10.1016/j.phytol.2026.104217

M3 - Journal article

AN - SCOPUS:105045322335

SN - 1874-3900

VL - 75

JO - Phytochemistry Letters

JF - Phytochemistry Letters

M1 - 104217

ER -

A new sesquiterpenoid with antibacterial activity from the leaves of Rosa rugosa

Abstract

Keywords

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