A novel gold-based molecular beacon for probing CNG DNA repeat sequences

Han Na Joo; Young Jun Seo

doi:10.1016/j.tetlet.2014.12.004

A novel gold-based molecular beacon for probing CNG DNA repeat sequences

Han Na Joo
, Young Jun Seo^*

^*Corresponding author for this work

Department of Chemistry

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

8 Scopus citations

Abstract

We designed and developed a novel gold-based molecular beacon that targets CAG and CTG DNA repeat sequences. In single-stranded closed-loop state, the gold-based CNG repeat probe is quenched by an attached gold nanoparticle. Upon encounter with its target CAG or CTG repeat sequence, the probe forms a linear duplex structure and exhibits increased emission signal. This is the first gold quencher-based molecular beacon targeting the CNG repeat.

Original language	English
Pages (from-to)	542-545
Number of pages	4
Journal	Tetrahedron Letters
Volume	56
Issue number	3
DOIs	https://doi.org/10.1016/j.tetlet.2014.12.004
State	Published - 2015.01.14

Keywords

CNG repeat
DNA
Fluorophore
Gold nanoparticles
Oligonucleotide

Quacquarelli Symonds(QS) Subject Topics

Engineering - Petroleum
Pharmacy & Pharmacology
Chemistry
Biological Sciences

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10.1016/j.tetlet.2014.12.004

Cite this

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title = "A novel gold-based molecular beacon for probing CNG DNA repeat sequences",

abstract = "We designed and developed a novel gold-based molecular beacon that targets CAG and CTG DNA repeat sequences. In single-stranded closed-loop state, the gold-based CNG repeat probe is quenched by an attached gold nanoparticle. Upon encounter with its target CAG or CTG repeat sequence, the probe forms a linear duplex structure and exhibits increased emission signal. This is the first gold quencher-based molecular beacon targeting the CNG repeat.",

keywords = "CNG repeat, DNA, Fluorophore, Gold nanoparticles, Oligonucleotide",

author = "Joo, \{Han Na\} and Seo, \{Young Jun\}",

year = "2015",

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journal = "Tetrahedron Letters",

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T1 - A novel gold-based molecular beacon for probing CNG DNA repeat sequences

AU - Joo, Han Na

AU - Seo, Young Jun

PY - 2015/1/14

Y1 - 2015/1/14

N2 - We designed and developed a novel gold-based molecular beacon that targets CAG and CTG DNA repeat sequences. In single-stranded closed-loop state, the gold-based CNG repeat probe is quenched by an attached gold nanoparticle. Upon encounter with its target CAG or CTG repeat sequence, the probe forms a linear duplex structure and exhibits increased emission signal. This is the first gold quencher-based molecular beacon targeting the CNG repeat.

AB - We designed and developed a novel gold-based molecular beacon that targets CAG and CTG DNA repeat sequences. In single-stranded closed-loop state, the gold-based CNG repeat probe is quenched by an attached gold nanoparticle. Upon encounter with its target CAG or CTG repeat sequence, the probe forms a linear duplex structure and exhibits increased emission signal. This is the first gold quencher-based molecular beacon targeting the CNG repeat.

KW - CNG repeat

KW - DNA

KW - Fluorophore

KW - Gold nanoparticles

KW - Oligonucleotide

UR - https://www.scopus.com/pages/publications/84920128220

U2 - 10.1016/j.tetlet.2014.12.004

DO - 10.1016/j.tetlet.2014.12.004

M3 - Journal article

AN - SCOPUS:84920128220

SN - 0040-4039

VL - 56

SP - 542

EP - 545

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 3

ER -

A novel gold-based molecular beacon for probing CNG DNA repeat sequences

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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