Abstract
In the screening for lipid peroxidation inhibitors from edible mushroom, Agrocybe cylindracea, a bioactive compound AG 8 was isolated. The AG 8 was purified from methanol extract of its fruit body by Diaion HP-20 column chromatography, ethyl acetate extraction, and silica gel column chromatography, consecutively. Based on various NMR studies including 1H irradiation and HMBC experiments, the AG 8 was identified as MTA, 5'-deoxy- 5'-methylthioadenosine. This compound inhibited lipid peroxidation with an IC50 value of 3.2 μg/ml. The MTA was isolated for the first time from basidiomycetes.
| Original language | English |
|---|---|
| Pages (from-to) | 558-561 |
| Number of pages | 4 |
| Journal | Korean Journal of Applied Microbiology and Biotechnology |
| Volume | 26 |
| Issue number | 6 |
| State | Published - 1998 |
Keywords
- 5'-deoxy-5'-methylthioadenosine
- Agrocybe cylindracea
- Lipid peroxidation inhibitor
- Mushroom
- NMR
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