A recent tendency of protein drug delivery system for bioefficacy improvement

To date, considerable attention has been devoted to development of the protein-drug delivery system although protein-drug is limited to extensive utilizations due to the short half-life and denaturalization in physiology condition. Thus, a number of drug delivery systems are developed in order to endow stability of protein drugs and to improve their bioefficacy. In this review, we describe the recent trend of protein drug delivery such as protein drug-polymer conjugation, nano-scale carriers, hydrogels, liposome-micelles and microcapsules, important in the understanding of the basic science for protein drug delivery.