An 8-wk, randomized, double-blind, placebo-controlled clinical trial for the antidiabetic effects of hydrolyzed ginseng extract

Background: To investigate the antidiabetic effects of hydrolyzed ginseng extract (HGE) for Koreanparticipants in an 8-wk, randomized, double-blinded, placebo-controlled clinical trial.Methods: Impaired fasting glucose participants fasting plasma glucose (FPG) 5.6mM or < 6.9mM]who had not been diagnosed with any disease and met the inclusion criteria were recruited for thisstudy. The 23 participants were randomly divided into either the HGE (n ¼ 12, 960 mg/d) or placebo(n ¼ 11) group. Outcomes included measurements of efficacy (FPG, postprandial glucose, fasting plasmainsulin, postprandial insulin, homeostatic model assessment-insulin resistance, and homeostatic modelassessment-b) and safety (adverse events, laboratory tests, electrocardiogram, and vital signs).Results: After 8 wk of HGE supplementation, FPG and postprandial glucose were significantly decreasedin the HGE group compared to the placebo group. No clinically significant changes in any safetyparameter were observed. Our study revealed that HGE is a potent antidiabetic agent that does notproduce noticeable adverse effects.Conclusion: HGE supplementation may be effective for treating impaired fasting glucose individuals.