An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration

Bae Hang Park; Sungho Kook; Sean Bong Lee; Jong Hyeon Jeong; Adam Brufsky; Byeong Chel Lee

doi:10.1074/jbc.M113.509505

An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration

Bae Hang Park
, Sungho Kook
, Sean Bong Lee
, Jong Hyeon Jeong
, Adam Brufsky
, Byeong Chel Lee^*

^*Corresponding author for this work

Department of Bioactive Material Sciences

Research output: Contribution to journal › Journal article › peer-review

25 Scopus citations

Abstract

Background:CXCR4/CXCL12 axis provides directional cues for breast cancer cells to metastasize to specific organs. Results:LIP regulates the expression of CXCR4, promoting CXCR4/CXCL12-mediated breast cancer cell migration. Conclusion:LIP is a previously unrecognized transcriptional regulator of CXCR4. Significance:Our results revealed a potential link between heregulin, LIP, and CXCR4 and may have important therapeutic implications for metastatic breast cancer.

Original language	English
Pages (from-to)	28656-28667
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.509505
State	Published - 2013.10.4

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Quacquarelli Symonds(QS) Subject Topics

Biological Sciences

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10.1074/jbc.M113.509505

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@article{20d2981dc61d4172856712298e3ab771,

title = "An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration",

abstract = "Background:CXCR4/CXCL12 axis provides directional cues for breast cancer cells to metastasize to specific organs. Results:LIP regulates the expression of CXCR4, promoting CXCR4/CXCL12-mediated breast cancer cell migration. Conclusion:LIP is a previously unrecognized transcriptional regulator of CXCR4. Significance:Our results revealed a potential link between heregulin, LIP, and CXCR4 and may have important therapeutic implications for metastatic breast cancer.",

author = "Park, \{Bae Hang\} and Sungho Kook and Lee, \{Sean Bong\} and Jeong, \{Jong Hyeon\} and Adam Brufsky and Lee, \{Byeong Chel\}",

year = "2013",

month = oct,

day = "4",

doi = "10.1074/jbc.M113.509505",

language = "English",

volume = "288",

pages = "28656--28667",

journal = "Journal of Biological Chemistry",

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TY - JOUR

T1 - An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration

AU - Park, Bae Hang

AU - Kook, Sungho

AU - Lee, Sean Bong

AU - Jeong, Jong Hyeon

AU - Brufsky, Adam

AU - Lee, Byeong Chel

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Background:CXCR4/CXCL12 axis provides directional cues for breast cancer cells to metastasize to specific organs. Results:LIP regulates the expression of CXCR4, promoting CXCR4/CXCL12-mediated breast cancer cell migration. Conclusion:LIP is a previously unrecognized transcriptional regulator of CXCR4. Significance:Our results revealed a potential link between heregulin, LIP, and CXCR4 and may have important therapeutic implications for metastatic breast cancer.

AB - Background:CXCR4/CXCL12 axis provides directional cues for breast cancer cells to metastasize to specific organs. Results:LIP regulates the expression of CXCR4, promoting CXCR4/CXCL12-mediated breast cancer cell migration. Conclusion:LIP is a previously unrecognized transcriptional regulator of CXCR4. Significance:Our results revealed a potential link between heregulin, LIP, and CXCR4 and may have important therapeutic implications for metastatic breast cancer.

UR - https://www.scopus.com/pages/publications/84885131386

U2 - 10.1074/jbc.M113.509505

DO - 10.1074/jbc.M113.509505

M3 - Journal article

C2 - 23966000

AN - SCOPUS:84885131386

SN - 0021-9258

VL - 288

SP - 28656

EP - 28667

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 40

ER -

An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration

Abstract

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