Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii

Byung Soon Hwang; In Kyoung Lee; Hwa Jung Choi; Bong Sik Yun

doi:10.1016/j.bmcl.2015.05.081

Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii

Byung Soon Hwang
, In Kyoung Lee
, Hwa Jung Choi
, Bong Sik Yun^*

^*Corresponding author for this work

Environmental Biotechnology

Jeonbuk National University
Kwangju Women's University

Research output: Contribution to journal › Journal article › peer-review

85 Scopus citations

Abstract

Abstract Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.

Original language	English
Pages (from-to)	3256-3260
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2015.05.081
State	Published - 2015.07.3

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-influenza
Cytopathic effect
Neuraminidase inhibition
Phellinus baumii
Polyphenol

Quacquarelli Symonds(QS) Subject Topics

Medicine
Engineering - Petroleum
Pharmacy & Pharmacology
Chemistry
Biological Sciences

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10.1016/j.bmcl.2015.05.081

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title = "Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii",

abstract = "Abstract Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.",

keywords = "Anti-influenza, Cytopathic effect, Neuraminidase inhibition, Phellinus baumii, Polyphenol",

author = "Hwang, \{Byung Soon\} and Lee, \{In Kyoung\} and Choi, \{Hwa Jung\} and Yun, \{Bong Sik\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = jul,

day = "3",

doi = "10.1016/j.bmcl.2015.05.081",

language = "English",

volume = "25",

pages = "3256--3260",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

number = "16",

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TY - JOUR

T1 - Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii

AU - Hwang, Byung Soon

AU - Lee, In Kyoung

AU - Choi, Hwa Jung

AU - Yun, Bong Sik

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Abstract Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.

AB - Abstract Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.

KW - Anti-influenza

KW - Cytopathic effect

KW - Neuraminidase inhibition

KW - Phellinus baumii

KW - Polyphenol

UR - https://www.scopus.com/pages/publications/84934836549

U2 - 10.1016/j.bmcl.2015.05.081

DO - 10.1016/j.bmcl.2015.05.081

M3 - Journal article

C2 - 26077494

AN - SCOPUS:84934836549

SN - 0960-894X

VL - 25

SP - 3256

EP - 3260

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

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