Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp

Soo Jin Choo; Bong Sik Yun; In Ja Ryoo; Young Hee Kim; Ki Hwan Bae; Ick Dong Yoo

doi:10.4014/jmb.0806.389

Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp

Soo Jin Choo
, Bong Sik Yun
, In Ja Ryoo
, Young Hee Kim
, Ki Hwan Bae
, Ick Dong Yoo^*

^*Corresponding author for this work

Environmental Biotechnology

Korea Research Institute of Bioscience and Biotechnology
Chungnam National University

Research output: Contribution to journal › Journal article › peer-review

8 Scopus citations

Abstract

In the course of screening for the melanogenesis inhibitors, aspochalasin I was isolated from solid-state culture of Aspergillus sp. Fb020460. Its structure was determined by spectroscopic analysis including mass spectroscopy and NMR analysis. Aspochalasin I potently inhibited melanogenesis in Mel-Ab cells with an IC₅₀ value of 22.4 μM without cytotoxicity.

Original language	English
Pages (from-to)	368-371
Number of pages	4
Journal	Journal of Microbiology and Biotechnology
Volume	19
Issue number	4
DOIs	https://doi.org/10.4014/jmb.0806.389
State	Published - 2009.04.28

Keywords

Aspergillus sp.
Aspochalasin I
Melanogenesis

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10.4014/jmb.0806.389

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title = "Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp",

abstract = "In the course of screening for the melanogenesis inhibitors, aspochalasin I was isolated from solid-state culture of Aspergillus sp. Fb020460. Its structure was determined by spectroscopic analysis including mass spectroscopy and NMR analysis. Aspochalasin I potently inhibited melanogenesis in Mel-Ab cells with an IC50 value of 22.4 μM without cytotoxicity.",

keywords = "Aspergillus sp., Aspochalasin I, Melanogenesis",

author = "Choo, \{Soo Jin\} and Yun, \{Bong Sik\} and Ryoo, \{In Ja\} and Kim, \{Young Hee\} and Bae, \{Ki Hwan\} and Yoo, \{Ick Dong\}",

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doi = "10.4014/jmb.0806.389",

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T1 - Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp

AU - Choo, Soo Jin

AU - Yun, Bong Sik

AU - Ryoo, In Ja

AU - Kim, Young Hee

AU - Bae, Ki Hwan

AU - Yoo, Ick Dong

PY - 2009/4/28

Y1 - 2009/4/28

N2 - In the course of screening for the melanogenesis inhibitors, aspochalasin I was isolated from solid-state culture of Aspergillus sp. Fb020460. Its structure was determined by spectroscopic analysis including mass spectroscopy and NMR analysis. Aspochalasin I potently inhibited melanogenesis in Mel-Ab cells with an IC50 value of 22.4 μM without cytotoxicity.

AB - In the course of screening for the melanogenesis inhibitors, aspochalasin I was isolated from solid-state culture of Aspergillus sp. Fb020460. Its structure was determined by spectroscopic analysis including mass spectroscopy and NMR analysis. Aspochalasin I potently inhibited melanogenesis in Mel-Ab cells with an IC50 value of 22.4 μM without cytotoxicity.

KW - Aspergillus sp.

KW - Aspochalasin I

KW - Melanogenesis

UR - https://www.scopus.com/pages/publications/67649312013

U2 - 10.4014/jmb.0806.389

DO - 10.4014/jmb.0806.389

M3 - Journal article

C2 - 19420992

AN - SCOPUS:67649312013

SN - 1017-7825

VL - 19

SP - 368

EP - 371

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

IS - 4

ER -

Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp

Abstract

Keywords

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