Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes

Kwang Hyun Park; Byung Ju Kim; Asif Iqbal Shawl; Myung Kwan Han; Hon Cheung Lee; Uh Hyun Kim

doi:10.1074/jbc.M113.489278

Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes

Kwang Hyun Park
, Byung Ju Kim
, Asif Iqbal Shawl
, Myung Kwan Han
, Hon Cheung Lee
, Uh Hyun Kim^*

^*Corresponding author for this work

Department of Medicine

Jeonbuk National University
Peking University

Research output: Contribution to journal › Journal article › peer-review

26 Scopus citations

Abstract

Background: External application of a Ca2⁺-mobilizing messenger, NAADP, toβ-cells activates intracellular Ca2⁺ changes and stimulates insulin secretion. Results: NAADP is transported into adipocytes and β-cells in a glucose-dependent manner and is also released from pancreatic islets upon stimulation by high glucose. Conclusion: NAADP functions in an auto-/paracrine manner to regulate glucose homeostasis. Significance: NAADP can be exploited as a potential antidiabetic agent.

Original language	English
Pages (from-to)	35548-35558
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	49
DOIs	https://doi.org/10.1074/jbc.M113.489278
State	Published - 2013.12.6

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Quacquarelli Symonds(QS) Subject Topics

Biological Sciences

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10.1074/jbc.M113.489278

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title = "Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes",

abstract = "Background: External application of a Ca2+-mobilizing messenger, NAADP, toβ-cells activates intracellular Ca2+ changes and stimulates insulin secretion. Results: NAADP is transported into adipocytes and β-cells in a glucose-dependent manner and is also released from pancreatic islets upon stimulation by high glucose. Conclusion: NAADP functions in an auto-/paracrine manner to regulate glucose homeostasis. Significance: NAADP can be exploited as a potential antidiabetic agent.",

author = "Park, \{Kwang Hyun\} and Kim, \{Byung Ju\} and Shawl, \{Asif Iqbal\} and Han, \{Myung Kwan\} and Lee, \{Hon Cheung\} and Kim, \{Uh Hyun\}",

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doi = "10.1074/jbc.M113.489278",

language = "English",

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T1 - Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes

AU - Park, Kwang Hyun

AU - Kim, Byung Ju

AU - Shawl, Asif Iqbal

AU - Han, Myung Kwan

AU - Lee, Hon Cheung

AU - Kim, Uh Hyun

PY - 2013/12/6

Y1 - 2013/12/6

N2 - Background: External application of a Ca2+-mobilizing messenger, NAADP, toβ-cells activates intracellular Ca2+ changes and stimulates insulin secretion. Results: NAADP is transported into adipocytes and β-cells in a glucose-dependent manner and is also released from pancreatic islets upon stimulation by high glucose. Conclusion: NAADP functions in an auto-/paracrine manner to regulate glucose homeostasis. Significance: NAADP can be exploited as a potential antidiabetic agent.

AB - Background: External application of a Ca2+-mobilizing messenger, NAADP, toβ-cells activates intracellular Ca2+ changes and stimulates insulin secretion. Results: NAADP is transported into adipocytes and β-cells in a glucose-dependent manner and is also released from pancreatic islets upon stimulation by high glucose. Conclusion: NAADP functions in an auto-/paracrine manner to regulate glucose homeostasis. Significance: NAADP can be exploited as a potential antidiabetic agent.

UR - https://www.scopus.com/pages/publications/84890284562

U2 - 10.1074/jbc.M113.489278

DO - 10.1074/jbc.M113.489278

M3 - Journal article

C2 - 24165120

AN - SCOPUS:84890284562

SN - 0021-9258

VL - 288

SP - 35548

EP - 35558

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 49

ER -

Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes

Abstract

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