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Bidirectional recurrent neural network approach for predicting cervical cancer recurrence and survival

  • S. Geeitha
  • , K. P.Rama Prabha
  • , Jaehyuk Cho*
  • , Sathishkumar Veerappampalayam Easwaramoorthy
  • *Corresponding author for this work
    • M.Kumarasamy College of Engineering
    • Vellore Institute of Technology
    • Sunway University

    Research output: Contribution to journalJournal articlepeer-review

    Abstract

    Cervical cancer is a deadly disease in women globally. There is a greater chance of getting rid of cervical cancer in case of earliest diagnosis. But for some patients, there is a chance of recurrence. The chances of treating the Recurrence of cervical carcinoma arelimited. The main objective of a research is to find the key features that will predict the cervical cancer recurrence and survival rates accurately by utilizing a neural network that is bidirectionally recurrent. The goal is to reduce risk factors of cervical cancer recurrence by identifying genes with positive coefficients and targeting them for preventive interventions. First step is identification of risk factors for cervical carcinoma recurrence by utilising clinical attributes. This research uses following Random forest, Logistic regression, Gradient boosting and support vector machine algorithms are applied for classification. Random forest offers the maximum precision of these four techniques at 91.2%. The second step is identifying long noncoding RNA (lnRNA) gene signatures among people with cervical carcinomaby implementingHSIC model. Intended to discover biomarkers in initial cervical carcinoma clinical data from people who experienced a distant repetition that could be connected to lnRNA gene signatures and utilized for forecasting survival rates using a bidirectional recurrent neural network(Bi-RNN). The results shows that Bi-RNN model effectively forecast the cervical cancer recurrence and survival.

    Original languageEnglish
    Article number31641
    JournalScientific Reports
    Volume14
    Issue number1
    DOIs
    StatePublished - 2024.12

    UN SDGs

    This output contributes to the following UN Sustainable Development Goals (SDGs)

    1. SDG 3 - Good Health and Well-being
      SDG 3 Good Health and Well-being

    Keywords

    • Machine learning
    • Recurrence cervical Cancer
    • Recurrent neural network
    • Risk factors
    • lnRNA

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