Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids

Jason D. Kang; Christopher J. Myers; Spencer C. Harris; Genta Kakiyama; In Kyoung Lee; Bong Sik Yun; Keiichi Matsuzaki; Megumi Furukawa; Hae Ki Min; Jasmohan S. Bajaj; Huiping Zhou; Phillip B. Hylemon

doi:10.1016/j.chembiol.2018.10.003

Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids

Jason D. Kang
, Christopher J. Myers
, Spencer C. Harris
, Genta Kakiyama
, In Kyoung Lee
, Bong Sik Yun
, Keiichi Matsuzaki
, Megumi Furukawa
, Hae Ki Min
, Jasmohan S. Bajaj
, Huiping Zhou
, Phillip B. Hylemon^*

^*Corresponding author for this work

Environmental Biotechnology

Research output: Contribution to journal › Journal article › peer-review

174 Scopus citations

Abstract

Kang et al. describe the discovery of tryptophan-derived antibiotics secreted by specific gut bacteria that inhibit C. difficile, a bacterial pathogen causing diarrhea and colitis. These results help explain why antibiotic treatment, which disrupts the normal protective gut microbiota, allows C. difficile to colonize the colon and cause disease.

Original language	English
Pages (from-to)	27-34.e4
Journal	Cell Chemical Biology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.chembiol.2018.10.003
State	Published - 2019.01.17

Keywords

1-acetyl-β-carboline
Clostridium difficile
Clostridium scindens
Clostridium sordellii
cyclic dipeptides
dysbiosis
gut microbiome
turbomycin A

Quacquarelli Symonds(QS) Subject Topics

Medicine
Pharmacy & Pharmacology
Biological Sciences

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10.1016/j.chembiol.2018.10.003

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Kang, J. D., Myers, C. J., Harris, S. C., Kakiyama, G., Lee, I. K., Yun, B. S., Matsuzaki, K., Furukawa, M., Min, H. K., Bajaj, J. S., Zhou, H., & Hylemon, P. B. (2019). Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids. Cell Chemical Biology, 26(1), 27-34.e4. https://doi.org/10.1016/j.chembiol.2018.10.003

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title = "Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids",

abstract = "Kang et al. describe the discovery of tryptophan-derived antibiotics secreted by specific gut bacteria that inhibit C. difficile, a bacterial pathogen causing diarrhea and colitis. These results help explain why antibiotic treatment, which disrupts the normal protective gut microbiota, allows C. difficile to colonize the colon and cause disease.",

keywords = "1-acetyl-β-carboline, Clostridium difficile, Clostridium scindens, Clostridium sordellii, cyclic dipeptides, dysbiosis, gut microbiome, turbomycin A",

author = "Kang, \{Jason D.\} and Myers, \{Christopher J.\} and Harris, \{Spencer C.\} and Genta Kakiyama and Lee, \{In Kyoung\} and Yun, \{Bong Sik\} and Keiichi Matsuzaki and Megumi Furukawa and Min, \{Hae Ki\} and Bajaj, \{Jasmohan S.\} and Huiping Zhou and Hylemon, \{Phillip B.\}",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2019",

month = jan,

day = "17",

doi = "10.1016/j.chembiol.2018.10.003",

language = "English",

volume = "26",

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T2 - Role of Secondary Bile Acids

AU - Kang, Jason D.

AU - Myers, Christopher J.

AU - Harris, Spencer C.

AU - Kakiyama, Genta

AU - Lee, In Kyoung

AU - Yun, Bong Sik

AU - Matsuzaki, Keiichi

AU - Furukawa, Megumi

AU - Min, Hae Ki

AU - Bajaj, Jasmohan S.

AU - Zhou, Huiping

AU - Hylemon, Phillip B.

PY - 2019/1/17

Y1 - 2019/1/17

N2 - Kang et al. describe the discovery of tryptophan-derived antibiotics secreted by specific gut bacteria that inhibit C. difficile, a bacterial pathogen causing diarrhea and colitis. These results help explain why antibiotic treatment, which disrupts the normal protective gut microbiota, allows C. difficile to colonize the colon and cause disease.

AB - Kang et al. describe the discovery of tryptophan-derived antibiotics secreted by specific gut bacteria that inhibit C. difficile, a bacterial pathogen causing diarrhea and colitis. These results help explain why antibiotic treatment, which disrupts the normal protective gut microbiota, allows C. difficile to colonize the colon and cause disease.

KW - 1-acetyl-β-carboline

KW - Clostridium difficile

KW - Clostridium scindens

KW - Clostridium sordellii

KW - cyclic dipeptides

KW - dysbiosis

KW - gut microbiome

KW - turbomycin A

UR - https://www.scopus.com/pages/publications/85059667892

U2 - 10.1016/j.chembiol.2018.10.003

DO - 10.1016/j.chembiol.2018.10.003

M3 - Journal article

C2 - 30482679

AN - SCOPUS:85059667892

SN - 2451-9456

VL - 26

SP - 27-34.e4

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 1

ER -

Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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