Bioactive secondary metabolites from Dentipellis fragilis with anti-inflammatory and cytotoxic activity

Dae Cheol Choi; Yoon Hee Kim; Min Ju Park; Da Young Hwang; Ji Yul Kim; Yeong Seon Won; In Kyoung Lee; Dae Won Ki; Bong Sik Yun

doi:10.1016/j.fitote.2025.106492

Bioactive secondary metabolites from Dentipellis fragilis with anti-inflammatory and cytotoxic activity

Dae Cheol Choi
, Yoon Hee Kim
, Min Ju Park
, Da Young Hwang
, Ji Yul Kim
, Yeong Seon Won
, In Kyoung Lee
, Dae Won Ki^*
, Bong Sik Yun

^*Corresponding author for this work

Environmental Biotechnology

Research output: Contribution to journal › Journal article › peer-review

Abstract

Two new compounds, a benzofuran derivative (1) and a benzoate derivative (2), along with four known γ-pyrones (3–6), were isolated from the culture broth of Dentipellis fragilis. Their chemical structures were elucidated via spectroscopic analysis. The anti-inflammatory and cytotoxic effects of these compounds were assessed. Compound 4 exhibited significant anti-inflammatory activity, inhibiting approximately 60 % of NO production at 0.005 μM without cytotoxic effects. Additionally, compound 2 showed moderate cytotoxicity against HCT-116 and Mia Paca-2 human cancer cells, with IC₅₀ values.

Original language	English
Article number	106492
Journal	Fitoterapia
Volume	183
DOIs	https://doi.org/10.1016/j.fitote.2025.106492
State	Published - 2025.06

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-inflammatory
Benzoate
Benzofuran
Cytotoxicity
Dentipellis fragilis
γ-Pyrones

Quacquarelli Symonds(QS) Subject Topics

Agriculture & Forestry
Pharmacy & Pharmacology

Access to Document

10.1016/j.fitote.2025.106492

Cite this

@article{ac6f7b0a66cb44c29ded55b25b95709c,

title = "Bioactive secondary metabolites from Dentipellis fragilis with anti-inflammatory and cytotoxic activity",

abstract = "Two new compounds, a benzofuran derivative (1) and a benzoate derivative (2), along with four known γ-pyrones (3–6), were isolated from the culture broth of Dentipellis fragilis. Their chemical structures were elucidated via spectroscopic analysis. The anti-inflammatory and cytotoxic effects of these compounds were assessed. Compound 4 exhibited significant anti-inflammatory activity, inhibiting approximately 60 \% of NO production at 0.005 μM without cytotoxic effects. Additionally, compound 2 showed moderate cytotoxicity against HCT-116 and Mia Paca-2 human cancer cells, with IC50 values.",

keywords = "Anti-inflammatory, Benzoate, Benzofuran, Cytotoxicity, Dentipellis fragilis, γ-Pyrones",

author = "Choi, \{Dae Cheol\} and Kim, \{Yoon Hee\} and Park, \{Min Ju\} and Hwang, \{Da Young\} and Kim, \{Ji Yul\} and Won, \{Yeong Seon\} and Lee, \{In Kyoung\} and Ki, \{Dae Won\} and Yun, \{Bong Sik\}",

note = "Publisher Copyright: {\textcopyright} 2025",

year = "2025",

month = jun,

doi = "10.1016/j.fitote.2025.106492",

language = "English",

volume = "183",

journal = "Fitoterapia",

issn = "0367-326X",

}

TY - JOUR

T1 - Bioactive secondary metabolites from Dentipellis fragilis with anti-inflammatory and cytotoxic activity

AU - Choi, Dae Cheol

AU - Kim, Yoon Hee

AU - Park, Min Ju

AU - Hwang, Da Young

AU - Kim, Ji Yul

AU - Won, Yeong Seon

AU - Lee, In Kyoung

AU - Ki, Dae Won

AU - Yun, Bong Sik

PY - 2025/6

Y1 - 2025/6

N2 - Two new compounds, a benzofuran derivative (1) and a benzoate derivative (2), along with four known γ-pyrones (3–6), were isolated from the culture broth of Dentipellis fragilis. Their chemical structures were elucidated via spectroscopic analysis. The anti-inflammatory and cytotoxic effects of these compounds were assessed. Compound 4 exhibited significant anti-inflammatory activity, inhibiting approximately 60 % of NO production at 0.005 μM without cytotoxic effects. Additionally, compound 2 showed moderate cytotoxicity against HCT-116 and Mia Paca-2 human cancer cells, with IC50 values.

AB - Two new compounds, a benzofuran derivative (1) and a benzoate derivative (2), along with four known γ-pyrones (3–6), were isolated from the culture broth of Dentipellis fragilis. Their chemical structures were elucidated via spectroscopic analysis. The anti-inflammatory and cytotoxic effects of these compounds were assessed. Compound 4 exhibited significant anti-inflammatory activity, inhibiting approximately 60 % of NO production at 0.005 μM without cytotoxic effects. Additionally, compound 2 showed moderate cytotoxicity against HCT-116 and Mia Paca-2 human cancer cells, with IC50 values.

KW - Anti-inflammatory

KW - Benzoate

KW - Benzofuran

KW - Cytotoxicity

KW - Dentipellis fragilis

KW - γ-Pyrones

UR - https://www.scopus.com/pages/publications/105000942551

U2 - 10.1016/j.fitote.2025.106492

DO - 10.1016/j.fitote.2025.106492

M3 - Journal article

C2 - 40122301

AN - SCOPUS:105000942551

SN - 0367-326X

VL - 183

JO - Fitoterapia

JF - Fitoterapia

M1 - 106492

ER -

Bioactive secondary metabolites from Dentipellis fragilis with anti-inflammatory and cytotoxic activity

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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