Blood electrolytes and metabolites in rat model of acute metabolic and respiratory alkalosis

The development of blood ionic changes could be precipitated in acid-base disorder and subsequent treatment. As technology for detecting circulating ionized Mg²⁺ (the most interesting form with respect to physiological and biological properties) is now available in veterinary clinical medicine. This present study investigated the changes of whole blood ionized Mg²⁺ correlated with acute metabolic and respiratory alkalosis in rodent model. Metabolic alkalosis was induced by intravenous infusion with NaHCO₃ and mechanical hyperventilation was applied for respiratory alkalosis. We founded that the blood ionized Mg²⁺ could be reversibly decreased by the NaHCO₃-induced acute metabolic alkalosis but irreversibly increased by the mechanical hyperventilation-induced respiratory acidosis and respiratory acidosis. We suggested that the potential change in blood suggested that the potential change in blood ionized Mg²⁺ should be counted in treatment of acid-base disorders.