CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/ CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy: A case report

Sun Woo Shin; Yu Jin Lim; Hyeona Bae; Jihu Kim; Arom Cho; Jinho Park; Dongbin Lee; Dong In Jung; Sang Ki Kim; Dohyeon Yu

doi:10.14405/kjvr.2021.61.e21

CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/ CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy: A case report

Sun Woo Shin
, Yu Jin Lim
, Hyeona Bae
, Jihu Kim
, Arom Cho
, Jinho Park
, Dongbin Lee
, Dong In Jung
, Sang Ki Kim^*
, Dohyeon Yu^*

^*Corresponding author for this work

Department of Veterinary Medicine

Gyeongsang National University
Kongju National University

Research output: Contribution to journal › Journal article › peer-review

6 Scopus citations

Abstract

Canine T-zone lymphoma (TZL) is a mature T-cell lymphoma in dogs. The diagnosis and sub-classification are impossible without biopsy or immunophenotyping by flow cytometry. An 11-year-old, spayed, female Golden Retriever presented with lymph node enlargement. Clinical examination was consistent with canine multicentric lymphoma. However, immunophenotyping revealed positive for CD3, CD4, CD5, CD8, CD21, TCRαβ, and MHCII but negative for CD34, CD45, CD79a, and TCRγδ. Histopathology revealed lymphocytes expanding to the cortex-preserving architecture and thinning of the nodal capsule, and CD3 positive but PAX-5 negative. Owing to the indolent nature of TZL, careful monitoring approach without clinical intervention was utilized.

Original language	English
Article number	e21
Journal	Korean Journal of Veterinary Research
Volume	61
Issue number	3
DOIs	https://doi.org/10.14405/kjvr.2021.61.e21
State	Published - 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Case report
Dog
Flow cytometry
Immunophenotyping
Lymphoma

Quacquarelli Symonds(QS) Subject Topics

Veterinary Science

Access to Document

10.14405/kjvr.2021.61.e21

Cite this

@article{9bba883386294d09bd6ad6783f220eb3,

title = "CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/ CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy: A case report",

abstract = "Canine T-zone lymphoma (TZL) is a mature T-cell lymphoma in dogs. The diagnosis and sub-classification are impossible without biopsy or immunophenotyping by flow cytometry. An 11-year-old, spayed, female Golden Retriever presented with lymph node enlargement. Clinical examination was consistent with canine multicentric lymphoma. However, immunophenotyping revealed positive for CD3, CD4, CD5, CD8, CD21, TCRαβ, and MHCII but negative for CD34, CD45, CD79a, and TCRγδ. Histopathology revealed lymphocytes expanding to the cortex-preserving architecture and thinning of the nodal capsule, and CD3 positive but PAX-5 negative. Owing to the indolent nature of TZL, careful monitoring approach without clinical intervention was utilized.",

keywords = "Case report, Dog, Flow cytometry, Immunophenotyping, Lymphoma",

author = "Shin, \{Sun Woo\} and Lim, \{Yu Jin\} and Hyeona Bae and Jihu Kim and Arom Cho and Jinho Park and Dongbin Lee and Jung, \{Dong In\} and Kim, \{Sang Ki\} and Dohyeon Yu",

note = "Publisher Copyright: {\textcopyright} 2021 The Korean Society of Veterinary Science.",

year = "2021",

doi = "10.14405/kjvr.2021.61.e21",

language = "English",

volume = "61",

journal = "Korean Journal of Veterinary Research",

issn = "2466-1384",

number = "3",

}

TY - JOUR

T1 - CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/ CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy

T2 - A case report

AU - Shin, Sun Woo

AU - Lim, Yu Jin

AU - Bae, Hyeona

AU - Kim, Jihu

AU - Cho, Arom

AU - Park, Jinho

AU - Lee, Dongbin

AU - Jung, Dong In

AU - Kim, Sang Ki

AU - Yu, Dohyeon

PY - 2021

Y1 - 2021

N2 - Canine T-zone lymphoma (TZL) is a mature T-cell lymphoma in dogs. The diagnosis and sub-classification are impossible without biopsy or immunophenotyping by flow cytometry. An 11-year-old, spayed, female Golden Retriever presented with lymph node enlargement. Clinical examination was consistent with canine multicentric lymphoma. However, immunophenotyping revealed positive for CD3, CD4, CD5, CD8, CD21, TCRαβ, and MHCII but negative for CD34, CD45, CD79a, and TCRγδ. Histopathology revealed lymphocytes expanding to the cortex-preserving architecture and thinning of the nodal capsule, and CD3 positive but PAX-5 negative. Owing to the indolent nature of TZL, careful monitoring approach without clinical intervention was utilized.

AB - Canine T-zone lymphoma (TZL) is a mature T-cell lymphoma in dogs. The diagnosis and sub-classification are impossible without biopsy or immunophenotyping by flow cytometry. An 11-year-old, spayed, female Golden Retriever presented with lymph node enlargement. Clinical examination was consistent with canine multicentric lymphoma. However, immunophenotyping revealed positive for CD3, CD4, CD5, CD8, CD21, TCRαβ, and MHCII but negative for CD34, CD45, CD79a, and TCRγδ. Histopathology revealed lymphocytes expanding to the cortex-preserving architecture and thinning of the nodal capsule, and CD3 positive but PAX-5 negative. Owing to the indolent nature of TZL, careful monitoring approach without clinical intervention was utilized.

KW - Case report

KW - Dog

KW - Flow cytometry

KW - Immunophenotyping

KW - Lymphoma

UR - https://www.scopus.com/pages/publications/85119187933

U2 - 10.14405/kjvr.2021.61.e21

DO - 10.14405/kjvr.2021.61.e21

M3 - Journal article

AN - SCOPUS:85119187933

SN - 2466-1384

VL - 61

JO - Korean Journal of Veterinary Research

JF - Korean Journal of Veterinary Research

IS - 3

M1 - e21

ER -

CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/ CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy: A case report

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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