Cell-laden microengineered and mechanically tunable hybrid hydrogels of gelatin and graphene oxide

Su Ryon Shin; Behnaz Aghaei-Ghareh-Bolagh; Tram T. Dang; Seda Nur Topkaya; Xiguang Gao; Seung Yun Yang; Sung Mi Jung; Jong Hyun Oh; Mehmet R. Dokmeci; Xiaowu Tang; Ali Khademhosseini

doi:10.1002/adma.201301082

Cell-laden microengineered and mechanically tunable hybrid hydrogels of gelatin and graphene oxide

Su Ryon Shin
, Behnaz Aghaei-Ghareh-Bolagh
, Tram T. Dang
, Seda Nur Topkaya
, Xiguang Gao
, Seung Yun Yang
, Sung Mi Jung
, Jong Hyun Oh
, Mehmet R. Dokmeci
, Xiaowu Tang^*
, Ali Khademhosseini

^*Corresponding author for this work

Nano-Bio Mechanical System Engineering

Research output: Contribution to journal › Journal article › peer-review

317 Scopus citations

Abstract

Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi-stacking approach offers a facile engineering strategy for the construction of complex artificial tissues.

Original language	English
Pages (from-to)	6385-6391
Number of pages	7
Journal	Advanced Materials
Volume	25
Issue number	44
DOIs	https://doi.org/10.1002/adma.201301082
State	Published - 2013.11.26

Keywords

graphene
microgels
multilayer constructs
tissue engineering
tunable stiffness

Quacquarelli Symonds(QS) Subject Topics

Engineering - Mechanical
Materials Science

Access to Document

10.1002/adma.201301082

Cite this

@article{6d39d7ce985e4a83956535954141ae9b,

title = "Cell-laden microengineered and mechanically tunable hybrid hydrogels of gelatin and graphene oxide",

abstract = "Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi-stacking approach offers a facile engineering strategy for the construction of complex artificial tissues.",

keywords = "graphene, microgels, multilayer constructs, tissue engineering, tunable stiffness",

author = "Shin, \{Su Ryon\} and Behnaz Aghaei-Ghareh-Bolagh and Dang, \{Tram T.\} and Topkaya, \{Seda Nur\} and Xiguang Gao and Yang, \{Seung Yun\} and Jung, \{Sung Mi\} and Oh, \{Jong Hyun\} and Dokmeci, \{Mehmet R.\} and Xiaowu Tang and Ali Khademhosseini",

year = "2013",

month = nov,

day = "26",

doi = "10.1002/adma.201301082",

language = "English",

volume = "25",

pages = "6385--6391",

journal = "Advanced Materials",

issn = "0935-9648",

number = "44",

}

TY - JOUR

T1 - Cell-laden microengineered and mechanically tunable hybrid hydrogels of gelatin and graphene oxide

AU - Shin, Su Ryon

AU - Aghaei-Ghareh-Bolagh, Behnaz

AU - Dang, Tram T.

AU - Topkaya, Seda Nur

AU - Gao, Xiguang

AU - Yang, Seung Yun

AU - Jung, Sung Mi

AU - Oh, Jong Hyun

AU - Dokmeci, Mehmet R.

AU - Tang, Xiaowu

AU - Khademhosseini, Ali

PY - 2013/11/26

Y1 - 2013/11/26

N2 - Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi-stacking approach offers a facile engineering strategy for the construction of complex artificial tissues.

AB - Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi-stacking approach offers a facile engineering strategy for the construction of complex artificial tissues.

KW - graphene

KW - microgels

KW - multilayer constructs

KW - tissue engineering

KW - tunable stiffness

UR - https://www.scopus.com/pages/publications/84888638734

U2 - 10.1002/adma.201301082

DO - 10.1002/adma.201301082

M3 - Journal article

C2 - 23996513

AN - SCOPUS:84888638734

SN - 0935-9648

VL - 25

SP - 6385

EP - 6391

JO - Advanced Materials

JF - Advanced Materials

IS - 44

ER -

Cell-laden microengineered and mechanically tunable hybrid hydrogels of gelatin and graphene oxide

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

Other files and links

Fingerprint

Cite this