Characterization and improved dissolution rate of Clopidogrel solid dispersion

Clopidogrel, effective for the prevention of ischemic stroke and myocardial infarction, is a poorly soluble drug with high crystallinity. In this study, the rotary evaporation method base on the solid dispersion method was used to increase the solubility of Clopidogrel drug. At this time, PVP K-30 was used as a water-soluble carrier, and poloxamer was used as a surfactant. Physicochemical analysis of solid dispersions containing Clopidogrel was carried out by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffractometry (XRD) and Fourier transform infrared spectroscopy (FTIR). It was possible to know that the solid dispersion was amorphous via SEM, DSC, and XRD. As a result of FTIR, it was confirmed that salt was formed through interaction between Clopidogrel and PVP K-30 molecule. Dissolution behavior in a simulated artificial gastric juice (pH 1.2) of Clopidogrel in the solid dispersions was measured using HPLC. As a result of comparing the dissolution rates with commercial Reyon Clopidogrel, it was confirmed that the solid dispersion dissolution rate through rotary evaporation was higher than Reyon Clopidogrel.