Characterization of a hybrid bone substitute composed of polylactic acid tetrapod chips and hydroxyapatite powder

So Hee Park; Sung Hee Park; Dae Sung Park; Yun Gyeong Kang; Ji Won Shin; Hyung Keun Kim; Taek Rim Yoon; Jung Woog Shin

doi:10.1007/s13770-013-0357-9

Characterization of a hybrid bone substitute composed of polylactic acid tetrapod chips and hydroxyapatite powder

So Hee Park
, Sung Hee Park
, Dae Sung Park
, Yun Gyeong Kang
, Ji Won Shin
, Hyung Keun Kim
, Taek Rim Yoon
, Jung Woog Shin^*

^*Corresponding author for this work

Department of Medicine

Research output: Contribution to journal › Journal article › peer-review

6 Scopus citations

Abstract

This study evaluated a novel bone substitute composed of biodegradable polylactic acid (PLA) chips and hydroxyapatite (HA) powder. Using a microinjection molding technique, we manufactured tetrapod-shaped PLA chips, which are known to resist external loading. The roughness of the chip surface allowed for cell attachment. Also, no in vitro toxicity or reduced cellular proliferation was observed. The HA powder, made from porcine trabecular bones, had been characterized in previous studies. In the animal studies, pasted HA powder and PLA were implanted into the defective rabbit tibia. The control group was not treated with HA and PLA powder. Using X-ray analysis, micro-computed tomography, hematoxylin and eosin staining, and pathological examination for 12 weeks, we confirmed that the PLA/HA hybrid bone substitute has a potential of clinical application.

Original language	English
Pages (from-to)	71-76
Number of pages	6
Journal	Tissue Engineering and Regenerative Medicine
Volume	10
Issue number	2
DOIs	https://doi.org/10.1007/s13770-013-0357-9
State	Published - 2013.04

Keywords

Hydroxyapatite
In vitro
In vivo
Microinjection molding technique
Polylactic acid
Tetrapod type

Quacquarelli Symonds(QS) Subject Topics

Medicine
Biological Sciences

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10.1007/s13770-013-0357-9

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title = "Characterization of a hybrid bone substitute composed of polylactic acid tetrapod chips and hydroxyapatite powder",

abstract = "This study evaluated a novel bone substitute composed of biodegradable polylactic acid (PLA) chips and hydroxyapatite (HA) powder. Using a microinjection molding technique, we manufactured tetrapod-shaped PLA chips, which are known to resist external loading. The roughness of the chip surface allowed for cell attachment. Also, no in vitro toxicity or reduced cellular proliferation was observed. The HA powder, made from porcine trabecular bones, had been characterized in previous studies. In the animal studies, pasted HA powder and PLA were implanted into the defective rabbit tibia. The control group was not treated with HA and PLA powder. Using X-ray analysis, micro-computed tomography, hematoxylin and eosin staining, and pathological examination for 12 weeks, we confirmed that the PLA/HA hybrid bone substitute has a potential of clinical application.",

keywords = "Hydroxyapatite, In vitro, In vivo, Microinjection molding technique, Polylactic acid, Tetrapod type",

author = "Park, \{So Hee\} and Park, \{Sung Hee\} and Park, \{Dae Sung\} and Kang, \{Yun Gyeong\} and Shin, \{Ji Won\} and Kim, \{Hyung Keun\} and Yoon, \{Taek Rim\} and Shin, \{Jung Woog\}",

year = "2013",

month = apr,

doi = "10.1007/s13770-013-0357-9",

language = "English",

volume = "10",

pages = "71--76",

journal = "Tissue Engineering and Regenerative Medicine",

issn = "1738-2696",

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TY - JOUR

T1 - Characterization of a hybrid bone substitute composed of polylactic acid tetrapod chips and hydroxyapatite powder

AU - Park, So Hee

AU - Park, Sung Hee

AU - Park, Dae Sung

AU - Kang, Yun Gyeong

AU - Shin, Ji Won

AU - Kim, Hyung Keun

AU - Yoon, Taek Rim

AU - Shin, Jung Woog

PY - 2013/4

Y1 - 2013/4

N2 - This study evaluated a novel bone substitute composed of biodegradable polylactic acid (PLA) chips and hydroxyapatite (HA) powder. Using a microinjection molding technique, we manufactured tetrapod-shaped PLA chips, which are known to resist external loading. The roughness of the chip surface allowed for cell attachment. Also, no in vitro toxicity or reduced cellular proliferation was observed. The HA powder, made from porcine trabecular bones, had been characterized in previous studies. In the animal studies, pasted HA powder and PLA were implanted into the defective rabbit tibia. The control group was not treated with HA and PLA powder. Using X-ray analysis, micro-computed tomography, hematoxylin and eosin staining, and pathological examination for 12 weeks, we confirmed that the PLA/HA hybrid bone substitute has a potential of clinical application.

AB - This study evaluated a novel bone substitute composed of biodegradable polylactic acid (PLA) chips and hydroxyapatite (HA) powder. Using a microinjection molding technique, we manufactured tetrapod-shaped PLA chips, which are known to resist external loading. The roughness of the chip surface allowed for cell attachment. Also, no in vitro toxicity or reduced cellular proliferation was observed. The HA powder, made from porcine trabecular bones, had been characterized in previous studies. In the animal studies, pasted HA powder and PLA were implanted into the defective rabbit tibia. The control group was not treated with HA and PLA powder. Using X-ray analysis, micro-computed tomography, hematoxylin and eosin staining, and pathological examination for 12 weeks, we confirmed that the PLA/HA hybrid bone substitute has a potential of clinical application.

KW - Hydroxyapatite

KW - In vitro

KW - In vivo

KW - Microinjection molding technique

KW - Polylactic acid

KW - Tetrapod type

UR - https://www.scopus.com/pages/publications/84896722851

U2 - 10.1007/s13770-013-0357-9

DO - 10.1007/s13770-013-0357-9

M3 - Journal article

AN - SCOPUS:84896722851

SN - 1738-2696

VL - 10

SP - 71

EP - 76

JO - Tissue Engineering and Regenerative Medicine

JF - Tissue Engineering and Regenerative Medicine

IS - 2

ER -

Characterization of a hybrid bone substitute composed of polylactic acid tetrapod chips and hydroxyapatite powder

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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