Chitosan derivatives as gene carriers

Tae Hee Kim; In Kyu Park; Su I.I. Kim; Hwan Jeong; Hee Seung Bom; Ng Su Cho

doi:10.4028/0-87849-967-9.97

Chitosan derivatives as gene carriers

Tae Hee Kim^*
, In Kyu Park
, Su I.I. Kim
, Hwan Jeong
, Hee Seung Bom
, Ng Su Cho

^*Corresponding author for this work

Department of Medicine

Seoul National University
Wonkwang University
Chonnam National University

Research output: Contribution to journal › Journal article › peer-review

3 Scopus citations

Abstract

Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review paper, chemical modification of chitosan for enhancement of cell specificity and transfection efficiency was explained. Also, chemical modification of chitosan for the stability of chitosan/DNA complexes was reviewed.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	Key Engineering Materials
Volume	288-289
DOIs	https://doi.org/10.4028/0-87849-967-9.97
State	Published - 2005

Keywords

Chemical modification
Chitosan
Gene carrier
Transfection efficiency

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10.4028/0-87849-967-9.97

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abstract = "Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review paper, chemical modification of chitosan for enhancement of cell specificity and transfection efficiency was explained. Also, chemical modification of chitosan for the stability of chitosan/DNA complexes was reviewed.",

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T1 - Chitosan derivatives as gene carriers

AU - Kim, Tae Hee

AU - Park, In Kyu

AU - Kim, Su I.I.

AU - Jeong, Hwan

AU - Bom, Hee Seung

AU - Cho, Ng Su

PY - 2005

Y1 - 2005

N2 - Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review paper, chemical modification of chitosan for enhancement of cell specificity and transfection efficiency was explained. Also, chemical modification of chitosan for the stability of chitosan/DNA complexes was reviewed.

AB - Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review paper, chemical modification of chitosan for enhancement of cell specificity and transfection efficiency was explained. Also, chemical modification of chitosan for the stability of chitosan/DNA complexes was reviewed.

KW - Chemical modification

KW - Chitosan

KW - Gene carrier

KW - Transfection efficiency

UR - https://www.scopus.com/pages/publications/34249678542

U2 - 10.4028/0-87849-967-9.97

DO - 10.4028/0-87849-967-9.97

M3 - Journal article

AN - SCOPUS:34249678542

SN - 1013-9826

VL - 288-289

SP - 97

EP - 100

JO - Key Engineering Materials

JF - Key Engineering Materials

ER -

Chitosan derivatives as gene carriers

Abstract

Keywords

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