Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern: A Case Report With Molecular Analysis

Woo Sung Moon; Ji Soo Song; Hee Chul Yu; Kyoung Min Kim; Ae Ri Ahn

doi:10.1177/10668969231168966

Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern: A Case Report With Molecular Analysis

Woo Sung Moon
, Ji Soo Song
, Hee Chul Yu
, Kyoung Min Kim^*
, Ae Ri Ahn^*

^*Corresponding author for this work

Department of Medicine

Research output: Contribution to journal › Journal article › peer-review

1 Scopus citations

Abstract

Combined hepatocellular-cholangiocarcinoma with a ductal plate malformation pattern is an extremely rare entity with unelucidated pathogenesis. We present the case of a 60-year-old male patient who underwent a sectionectomy for pre-operative diagnosis of hepatocellular carcinoma based on clinical and image findings. Gross examination of the specimen revealed a well-defined tumor with cystic change measuring 6.7 × 6.2 cm. Microscopically, the lesion had classical features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma exhibited neoplastic glands with irregular-sized dilated lumens, resembling a ductal plate malformation. Postoperative diagnosis was combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern. Next-generation sequencing revealed genomic alteration in 15 genes: CDKN2A, CHD4, CYP2D6, ERBB3, KIR3DL1, KRAS, MDM2, PIM1, STAT6, TPMT amplification, FANCD2, FAT1, FLT4, RASA1, and TP53 point mutation. This is the first case report of molecular alteration in combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern.

Original language	English
Pages (from-to)	160-164
Number of pages	5
Journal	International Journal of Surgical Pathology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1177/10668969231168966
State	Published - 2024.02

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

immunohistochemistry
liver
next-generation sequencing

Quacquarelli Symonds(QS) Subject Topics

Anatomy & Physiology
Medicine

Access to Document

10.1177/10668969231168966

Cite this

@article{6f5db8310b0f4347aa12251863883f6d,

title = "Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern: A Case Report With Molecular Analysis",

abstract = "Combined hepatocellular-cholangiocarcinoma with a ductal plate malformation pattern is an extremely rare entity with unelucidated pathogenesis. We present the case of a 60-year-old male patient who underwent a sectionectomy for pre-operative diagnosis of hepatocellular carcinoma based on clinical and image findings. Gross examination of the specimen revealed a well-defined tumor with cystic change measuring 6.7 {\texttimes} 6.2 cm. Microscopically, the lesion had classical features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma exhibited neoplastic glands with irregular-sized dilated lumens, resembling a ductal plate malformation. Postoperative diagnosis was combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern. Next-generation sequencing revealed genomic alteration in 15 genes: CDKN2A, CHD4, CYP2D6, ERBB3, KIR3DL1, KRAS, MDM2, PIM1, STAT6, TPMT amplification, FANCD2, FAT1, FLT4, RASA1, and TP53 point mutation. This is the first case report of molecular alteration in combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern.",

keywords = "immunohistochemistry, liver, next-generation sequencing",

author = "Moon, \{Woo Sung\} and Song, \{Ji Soo\} and Yu, \{Hee Chul\} and Kim, \{Kyoung Min\} and Ahn, \{Ae Ri\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",

year = "2024",

month = feb,

doi = "10.1177/10668969231168966",

language = "English",

volume = "32",

pages = "160--164",

journal = "International Journal of Surgical Pathology",

issn = "1066-8969",

number = "1",

}

TY - JOUR

T1 - Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern

T2 - A Case Report With Molecular Analysis

AU - Moon, Woo Sung

AU - Song, Ji Soo

AU - Yu, Hee Chul

AU - Kim, Kyoung Min

AU - Ahn, Ae Ri

N1 - Publisher Copyright: © The Author(s) 2023.

PY - 2024/2

Y1 - 2024/2

N2 - Combined hepatocellular-cholangiocarcinoma with a ductal plate malformation pattern is an extremely rare entity with unelucidated pathogenesis. We present the case of a 60-year-old male patient who underwent a sectionectomy for pre-operative diagnosis of hepatocellular carcinoma based on clinical and image findings. Gross examination of the specimen revealed a well-defined tumor with cystic change measuring 6.7 × 6.2 cm. Microscopically, the lesion had classical features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma exhibited neoplastic glands with irregular-sized dilated lumens, resembling a ductal plate malformation. Postoperative diagnosis was combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern. Next-generation sequencing revealed genomic alteration in 15 genes: CDKN2A, CHD4, CYP2D6, ERBB3, KIR3DL1, KRAS, MDM2, PIM1, STAT6, TPMT amplification, FANCD2, FAT1, FLT4, RASA1, and TP53 point mutation. This is the first case report of molecular alteration in combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern.

AB - Combined hepatocellular-cholangiocarcinoma with a ductal plate malformation pattern is an extremely rare entity with unelucidated pathogenesis. We present the case of a 60-year-old male patient who underwent a sectionectomy for pre-operative diagnosis of hepatocellular carcinoma based on clinical and image findings. Gross examination of the specimen revealed a well-defined tumor with cystic change measuring 6.7 × 6.2 cm. Microscopically, the lesion had classical features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma exhibited neoplastic glands with irregular-sized dilated lumens, resembling a ductal plate malformation. Postoperative diagnosis was combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern. Next-generation sequencing revealed genomic alteration in 15 genes: CDKN2A, CHD4, CYP2D6, ERBB3, KIR3DL1, KRAS, MDM2, PIM1, STAT6, TPMT amplification, FANCD2, FAT1, FLT4, RASA1, and TP53 point mutation. This is the first case report of molecular alteration in combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern.

KW - immunohistochemistry

KW - liver

KW - next-generation sequencing

UR - https://www.scopus.com/pages/publications/85158838011

U2 - 10.1177/10668969231168966

DO - 10.1177/10668969231168966

M3 - Journal article

C2 - 37128663

AN - SCOPUS:85158838011

SN - 1066-8969

VL - 32

SP - 160

EP - 164

JO - International Journal of Surgical Pathology

JF - International Journal of Surgical Pathology

IS - 1

ER -

Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern: A Case Report With Molecular Analysis

Abstract

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Quacquarelli Symonds(QS) Subject Topics

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Jeonbuk National University Medical School Researcher Targets Cholangiocarcinoma (Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern: A Case Report With Molecular Analysis)

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Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern: A Case Report With Molecular Analysis

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

Other files and links

Fingerprint

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Jeonbuk National University Medical School Researcher Targets Cholangiocarcinoma (Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern: A Case Report With Molecular Analysis)

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