Abstract
This study was designed to find an appropriate biomaterial to proliferate Schwann cell (SC). Poly(lactic-co-glycolic acid) (PLGA) films mixed with demineralized bone particle (DBP), small intestine submucosa (SIS), and silk were fabricated by a solvent casting method. Analysis of MTT, SEM and RT-PCR were performed to confirm adhesion and proliferation of SC. Contact angle of films was assayed for hydrophilicity of films. We confirmed that PLGA/DBP 20% film showed higher hydrophilicity, promoted adhesion and proliferation of SC than other.films. It was concluded that PLGA/DBP film can be applied for the scaffold biomaterials for the regeneration of central nerve system.
| Original language | English |
|---|---|
| Pages (from-to) | 164-170 |
| Number of pages | 7 |
| Journal | Polymer (Korea) |
| Volume | 38 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2014.03 |
Keywords
- Demineralized bone particle (DBP)
- PLGA hybridized film
- Schwann cell
- Silk
- Small intestine submucosa (SIS)
Quacquarelli Symonds(QS) Subject Topics
- Materials Science
- Engineering - Chemical
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