Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases

Jae Won Hyun; Hye Lim Lee; Woo Kyo Jeong; Hye Jung Lee; Jong Hwa Shin; Ju Hong Min; Byoung Joon Kim; Seung Woo Kim; Ha Young Shin; Jeeyoung Oh; Woojun Kim; Hyun June Shin; Sun Young Oh; Hyunjin Kim; Young Min Lim; So Young Huh; Eun Bin Cho; Tai Seung Nam; Seung Han Lee; Sun Young Kim; Sa Yoon Kang; Suk Geun Han; Eun Hee Sohn; Seol Hee Baek; Byung Jo Kim; Sang Soo Lee; Jin Myoung Seok; Yoon Ho Hong; Seong Il Oh; Jong Kuk Kim; Kyong Jin Shin; Ohyun Kwon; Joong Yang Cho; Jong Seok Bae; So Yeon Kim; Yeseul Kim; Min Young Lee; Su Hyun Kim; Ho Jin Kim

doi:10.1177/1352458520948213

Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases

Jae Won Hyun
, Hye Lim Lee
, Woo Kyo Jeong
, Hye Jung Lee
, Jong Hwa Shin
, Ju Hong Min
, Byoung Joon Kim
, Seung Woo Kim
, Ha Young Shin
, Jeeyoung Oh
, Woojun Kim
, Hyun June Shin
, Sun Young Oh
, Hyunjin Kim
, Young Min Lim
, So Young Huh
, Eun Bin Cho
, Tai Seung Nam
, Seung Han Lee
, Sun Young Kim

Sa Yoon Kang, Suk Geun Han, Eun Hee Sohn, Seol Hee Baek, Byung Jo Kim, Sang Soo Lee, Jin Myoung Seok, Yoon Ho Hong, Seong Il Oh, Jong Kuk Kim, Kyong Jin Shin, Ohyun Kwon, Joong Yang Cho, Jong Seok Bae, So Yeon Kim, Yeseul Kim, Min Young Lee, Su Hyun Kim, Ho Jin Kim^*

^*Corresponding author for this work

Department of Medicine

Research output: Contribution to journal › Journal article › peer-review

13 Scopus citations

Abstract

We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell–based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.

Original language	English
Pages (from-to)	964-967
Number of pages	4
Journal	Multiple Sclerosis Journal
Volume	27
Issue number	6
DOIs	https://doi.org/10.1177/1352458520948213
State	Published - 2021.05

Keywords

adult
Aquaporin-4
myelin oligodendrocyte glycoprotein
prevalence

Quacquarelli Symonds(QS) Subject Topics

Medicine

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10.1177/1352458520948213

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Hyun, J. W., Lee, H. L., Jeong, W. K., Lee, H. J., Shin, J. H., Min, J. H., Kim, B. J., Kim, S. W., Shin, H. Y., Oh, J., Kim, W., Shin, H. J., Oh, S. Y., Kim, H., Lim, Y. M., Huh, S. Y., Cho, E. B., Nam, T. S., Lee, S. H., ... Kim, H. J. (2021). Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases. Multiple Sclerosis Journal, 27(6), 964-967. https://doi.org/10.1177/1352458520948213

@article{86b3727713ba4346b901fe95b7b9edc1,

title = "Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases",

abstract = "We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell–based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1\%) and 185 (31.6\%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.",

keywords = "adult, Aquaporin-4, myelin oligodendrocyte glycoprotein, prevalence",

author = "Hyun, \{Jae Won\} and Lee, \{Hye Lim\} and Jeong, \{Woo Kyo\} and Lee, \{Hye Jung\} and Shin, \{Jong Hwa\} and Min, \{Ju Hong\} and Kim, \{Byoung Joon\} and Kim, \{Seung Woo\} and Shin, \{Ha Young\} and Jeeyoung Oh and Woojun Kim and Shin, \{Hyun June\} and Oh, \{Sun Young\} and Hyunjin Kim and Lim, \{Young Min\} and Huh, \{So Young\} and Cho, \{Eun Bin\} and Nam, \{Tai Seung\} and Lee, \{Seung Han\} and Kim, \{Sun Young\} and Kang, \{Sa Yoon\} and Han, \{Suk Geun\} and Sohn, \{Eun Hee\} and Baek, \{Seol Hee\} and Kim, \{Byung Jo\} and Lee, \{Sang Soo\} and Seok, \{Jin Myoung\} and Hong, \{Yoon Ho\} and Oh, \{Seong Il\} and Kim, \{Jong Kuk\} and Shin, \{Kyong Jin\} and Ohyun Kwon and Cho, \{Joong Yang\} and Bae, \{Jong Seok\} and Kim, \{So Yeon\} and Yeseul Kim and Lee, \{Min Young\} and Kim, \{Su Hyun\} and Kim, \{Ho Jin\}",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2020.",

year = "2021",

month = may,

doi = "10.1177/1352458520948213",

language = "English",

volume = "27",

pages = "964--967",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

number = "6",

}

Hyun, JW, Lee, HL, Jeong, WK, Lee, HJ, Shin, JH, Min, JH, Kim, BJ, Kim, SW, Shin, HY, Oh, J, Kim, W, Shin, HJ, Oh, SY, Kim, H, Lim, YM, Huh, SY, Cho, EB, Nam, TS, Lee, SH, Kim, SY, Kang, SY, Han, SG, Sohn, EH, Baek, SH, Kim, BJ, Lee, SS, Seok, JM, Hong, YH, Oh, SI, Kim, JK, Shin, KJ, Kwon, O, Cho, JY, Bae, JS, Kim, SY, Kim, Y, Lee, MY, Kim, SH & Kim, HJ 2021, 'Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases', Multiple Sclerosis Journal, vol. 27, no. 6, pp. 964-967. https://doi.org/10.1177/1352458520948213

TY - JOUR

T1 - Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases

AU - Hyun, Jae Won

AU - Lee, Hye Lim

AU - Jeong, Woo Kyo

AU - Lee, Hye Jung

AU - Shin, Jong Hwa

AU - Min, Ju Hong

AU - Kim, Byoung Joon

AU - Kim, Seung Woo

AU - Shin, Ha Young

AU - Oh, Jeeyoung

AU - Kim, Woojun

AU - Shin, Hyun June

AU - Oh, Sun Young

AU - Kim, Hyunjin

AU - Lim, Young Min

AU - Huh, So Young

AU - Cho, Eun Bin

AU - Nam, Tai Seung

AU - Lee, Seung Han

AU - Kim, Sun Young

AU - Kang, Sa Yoon

AU - Han, Suk Geun

AU - Sohn, Eun Hee

AU - Baek, Seol Hee

AU - Kim, Byung Jo

AU - Lee, Sang Soo

AU - Seok, Jin Myoung

AU - Hong, Yoon Ho

AU - Oh, Seong Il

AU - Kim, Jong Kuk

AU - Shin, Kyong Jin

AU - Kwon, Ohyun

AU - Cho, Joong Yang

AU - Bae, Jong Seok

AU - Kim, So Yeon

AU - Kim, Yeseul

AU - Lee, Min Young

AU - Kim, Su Hyun

AU - Kim, Ho Jin

PY - 2021/5

Y1 - 2021/5

N2 - We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell–based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.

AB - We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell–based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.

KW - adult

KW - Aquaporin-4

KW - myelin oligodendrocyte glycoprotein

KW - prevalence

UR - https://www.scopus.com/pages/publications/85089297974

U2 - 10.1177/1352458520948213

DO - 10.1177/1352458520948213

M3 - Journal article

C2 - 32779521

AN - SCOPUS:85089297974

SN - 1352-4585

VL - 27

SP - 964

EP - 967

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 6

ER -

Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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