Concomitant myocardial injury and brain lesions in three dogs

Three dogs were referred for evaluation of neurologic deficits due to seizure activity. Although they showed cardiac arrhythmias during physical examination and electrocardiographic recording, there were no functional and anatomical abnormalities of the hearts on echocardiographic examination. Marked elevation of serum cTnl and CKMB was confirmed. On magnetic resonance imaging (MRI) of the three dogs, central nervous system (CNS) inflammation on the pons-medullary and right cerebral areas was highly suspected. The clinical signs improved after prednisolone and cyclosporine administration, and the levels of cardiac markers decreased. This report described the clinical findings, specific cardiac enzymes, MRI features of the brain and response of treatment in suspected concomitant myocardial injury and brain lesions in three dogs.