Abstract
In this study, a multi-layered pellet was composed of a seed layer including a water-swellable agent and a drug layer containing doxazosin as a model drug, a porous membrane and a castor oil layer to control drug release. The pellet is prepared by a fluidized bed coating method. To confirm drug release from polymer blending in multi-layered pellet system, it is prepared by containing different ratio such as hydroxypropylmethylcellulose (HPMC) : ethyl cellulose (EC) in drug layer and cellulose acetate (CA) : Eudragit RS in membrane. Also, to confirm the effect of oil in drug release, castor oil is coated. As a result, we observed regularly spherical pellet with diameter of 1500 μm. Release pattern of drug is confirmed by dissolution tester in aqueous media. The more the ratio of EC in drug layer. CA in membrane, and castor oil layer in pellet, the less the drug release is observed. Formation and the amount of pores in membrane is observed by SEM.
| Original language | English |
|---|---|
| Pages (from-to) | 322-327 |
| Number of pages | 6 |
| Journal | Polymer (Korea) |
| Volume | 32 |
| Issue number | 4 |
| State | Published - 2008.07 |
Keywords
- Castor oil
- Cellulose acetate
- Doxazosin mesylate
- Drug release
- Fluidized-bed coater
Quacquarelli Symonds(QS) Subject Topics
- Materials Science
- Engineering - Chemical
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