Controlled release of pioglitazone HCl by solid dispersion with hydroxypropyl methylcellulose

This study was carried out to find the formation of solid dispersion for overcoming initial burst of pioglitazone HCl. We prepared pioglitazone HCl solid dispersion as contents of polymeric material as hydroxypropyl methylcellulose(HPMC). HPMC is the most important hydrophilic carrier used for the preparation of oral controlled drug delivery systems. One of its most important characteristics is the high swellability, which has a significant effect on the release kinetics of an incorporated drug. We analyzed surface of solid dispersed sample by scanning electron microscope(SEM) and X-ray diffraction(XRD) was used to analyze the crystallinity. Also the change of structure and crystallinity characteristic of solid dispersion tablet were analyzed by fourier-transform infrared spectoscopy (FT-IR). We prepared tablet with solid dispersion by direct compression and observed in vitro release behavior of solid dispersion from tablets in gastric juice(pH 1.2). The result was compared with release behavior of commercial drug(Actos®) and solid disperesd pioglitazone HCl.