Curcumin Encapsulated Micellar Nanoplatform for Blue Light Emitting Diode Induced Apoptosis as a New Class of Cancer Therapy

Berwin Singh Swami Vetha; Eun Mi Kim; Phil Sun Oh; Suhn Hee Kim; Seok Tae Lim; Myung Hee Sohn; Hwan Jeong Jeong

doi:10.1007/s13233-019-7168-3

Curcumin Encapsulated Micellar Nanoplatform for Blue Light Emitting Diode Induced Apoptosis as a New Class of Cancer Therapy

Berwin Singh Swami Vetha
, Eun Mi Kim
, Phil Sun Oh
, Suhn Hee Kim
, Seok Tae Lim
, Myung Hee Sohn
, Hwan Jeong Jeong^*

^*Corresponding author for this work

Department of Medicine

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

18 Scopus citations

Abstract

Blue light emitting diode (BLED) were known to inhibit cancer proliferation and induced apoptotic cell death by increasing intracellular reactive oxygen species (ROS) and caspase activation. However, not many attempts were made to study the naturally occurring photosensitizer molecule (PS) curcuminoids (CUR) mediated blue light emitting diode induced photodynamic therapy (BLED-PDT). Here, we demonstrated the use of pluronic F127 nanoplatform as a novel BLED-PDT based system for anticancer therapy. Aqueous soluble F127-CUR was proven to significantly mediate BLED-PDT, we anticipate that F127-CUR combined with BLED to induce BLED-PDT could be a promising cancer treatment modality.[Figure not available: see fulltext.].

Original language	English
Pages (from-to)	1179-1184
Number of pages	6
Journal	Macromolecular Research
Volume	27
Issue number	12
DOIs	https://doi.org/10.1007/s13233-019-7168-3
State	Published - 2019.12.1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

anti-cancer
BLED-PDT
micelles
photodynamic therapy

Quacquarelli Symonds(QS) Subject Topics

Materials Science
Engineering - Petroleum
Engineering - Chemical
Chemistry

Access to Document

10.1007/s13233-019-7168-3

Cite this

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title = "Curcumin Encapsulated Micellar Nanoplatform for Blue Light Emitting Diode Induced Apoptosis as a New Class of Cancer Therapy",

abstract = "Blue light emitting diode (BLED) were known to inhibit cancer proliferation and induced apoptotic cell death by increasing intracellular reactive oxygen species (ROS) and caspase activation. However, not many attempts were made to study the naturally occurring photosensitizer molecule (PS) curcuminoids (CUR) mediated blue light emitting diode induced photodynamic therapy (BLED-PDT). Here, we demonstrated the use of pluronic F127 nanoplatform as a novel BLED-PDT based system for anticancer therapy. Aqueous soluble F127-CUR was proven to significantly mediate BLED-PDT, we anticipate that F127-CUR combined with BLED to induce BLED-PDT could be a promising cancer treatment modality.[Figure not available: see fulltext.].",

keywords = "anti-cancer, BLED-PDT, micelles, photodynamic therapy",

author = "Vetha, \{Berwin Singh Swami\} and Kim, \{Eun Mi\} and Oh, \{Phil Sun\} and Kim, \{Suhn Hee\} and Lim, \{Seok Tae\} and Sohn, \{Myung Hee\} and Jeong, \{Hwan Jeong\}",

note = "Publisher Copyright: {\textcopyright} 2019, The Polymer Society of Korea and Springer.",

year = "2019",

month = dec,

day = "1",

doi = "10.1007/s13233-019-7168-3",

language = "English",

volume = "27",

pages = "1179--1184",

journal = "Macromolecular Research",

issn = "1598-5032",

number = "12",

}

TY - JOUR

T1 - Curcumin Encapsulated Micellar Nanoplatform for Blue Light Emitting Diode Induced Apoptosis as a New Class of Cancer Therapy

AU - Vetha, Berwin Singh Swami

AU - Kim, Eun Mi

AU - Oh, Phil Sun

AU - Kim, Suhn Hee

AU - Lim, Seok Tae

AU - Sohn, Myung Hee

AU - Jeong, Hwan Jeong

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Blue light emitting diode (BLED) were known to inhibit cancer proliferation and induced apoptotic cell death by increasing intracellular reactive oxygen species (ROS) and caspase activation. However, not many attempts were made to study the naturally occurring photosensitizer molecule (PS) curcuminoids (CUR) mediated blue light emitting diode induced photodynamic therapy (BLED-PDT). Here, we demonstrated the use of pluronic F127 nanoplatform as a novel BLED-PDT based system for anticancer therapy. Aqueous soluble F127-CUR was proven to significantly mediate BLED-PDT, we anticipate that F127-CUR combined with BLED to induce BLED-PDT could be a promising cancer treatment modality.[Figure not available: see fulltext.].

AB - Blue light emitting diode (BLED) were known to inhibit cancer proliferation and induced apoptotic cell death by increasing intracellular reactive oxygen species (ROS) and caspase activation. However, not many attempts were made to study the naturally occurring photosensitizer molecule (PS) curcuminoids (CUR) mediated blue light emitting diode induced photodynamic therapy (BLED-PDT). Here, we demonstrated the use of pluronic F127 nanoplatform as a novel BLED-PDT based system for anticancer therapy. Aqueous soluble F127-CUR was proven to significantly mediate BLED-PDT, we anticipate that F127-CUR combined with BLED to induce BLED-PDT could be a promising cancer treatment modality.[Figure not available: see fulltext.].

KW - anti-cancer

KW - BLED-PDT

KW - micelles

KW - photodynamic therapy

UR - https://www.scopus.com/pages/publications/85074049836

U2 - 10.1007/s13233-019-7168-3

DO - 10.1007/s13233-019-7168-3

M3 - Journal article

AN - SCOPUS:85074049836

SN - 1598-5032

VL - 27

SP - 1179

EP - 1184

JO - Macromolecular Research

JF - Macromolecular Research

IS - 12

ER -

Curcumin Encapsulated Micellar Nanoplatform for Blue Light Emitting Diode Induced Apoptosis as a New Class of Cancer Therapy

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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