Cyclo(dehydroala-L-Leu), an α-glucosidase inhibitor from Penicillium sp. F70614

O. S. Kwon; S. H. Park; B. S. Yun; Y. R. Pyun; C. J. Kim

doi:10.7164/antibiotics.53.954

Cyclo(dehydroala-L-Leu), an α-glucosidase inhibitor from Penicillium sp. F70614

O. S. Kwon
, S. H. Park
, B. S. Yun
, Y. R. Pyun
, C. J. Kim^*

^*Corresponding author for this work

Environmental Biotechnology

Korea Research Institute of Bioscience and Biotechnology

Research output: Contribution to journal › Journal article › peer-review

52 Scopus citations

Abstract

A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast α-glucosidase and porcine intestinal α-glucosidase with IC₅₀ values of 35 and 50 μg/ml, respectively. However, it did not show significant inhibitory effects against almond β-glucosidase, Aspergillus α-galactosidase, Escherichia coli β-galactosidase and jack bean α-mannosidase.

Original language	English
Pages (from-to)	954-958
Number of pages	5
Journal	Journal of Antibiotics
Volume	53
Issue number	9
DOIs	https://doi.org/10.7164/antibiotics.53.954
State	Published - 2000

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title = "Cyclo(dehydroala-L-Leu), an α-glucosidase inhibitor from Penicillium sp. F70614",

abstract = "A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast α-glucosidase and porcine intestinal α-glucosidase with IC50 values of 35 and 50 μg/ml, respectively. However, it did not show significant inhibitory effects against almond β-glucosidase, Aspergillus α-galactosidase, Escherichia coli β-galactosidase and jack bean α-mannosidase.",

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AU - Kwon, O. S.

AU - Park, S. H.

AU - Yun, B. S.

AU - Pyun, Y. R.

AU - Kim, C. J.

PY - 2000

Y1 - 2000

N2 - A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast α-glucosidase and porcine intestinal α-glucosidase with IC50 values of 35 and 50 μg/ml, respectively. However, it did not show significant inhibitory effects against almond β-glucosidase, Aspergillus α-galactosidase, Escherichia coli β-galactosidase and jack bean α-mannosidase.

AB - A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast α-glucosidase and porcine intestinal α-glucosidase with IC50 values of 35 and 50 μg/ml, respectively. However, it did not show significant inhibitory effects against almond β-glucosidase, Aspergillus α-galactosidase, Escherichia coli β-galactosidase and jack bean α-mannosidase.

UR - https://www.scopus.com/pages/publications/0033779051

U2 - 10.7164/antibiotics.53.954

DO - 10.7164/antibiotics.53.954

M3 - Journal article

C2 - 11099229

AN - SCOPUS:0033779051

SN - 0021-8820

VL - 53

SP - 954

EP - 958

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 9

ER -

Cyclo(dehydroala-L-Leu), an α-glucosidase inhibitor from Penicillium sp. F70614

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