Decursin from Angelica gigas nakai blocks hkv1.5 channel

Yong Geun Kwak; Bok Hee Choi; Dae Keun Kim; Jae Soon Eun

doi:10.4062/biomolther.2011.19.1.033

Decursin from Angelica gigas nakai blocks hkv1.5 channel

Yong Geun Kwak
, Bok Hee Choi
, Dae Keun Kim
, Jae Soon Eun

Department of Medicine

Woosuk University

Research output: Contribution to journal › Journal article › peer-review

2 Scopus citations

Abstract

Decursin was purifi ed from Angelica gigas Nakai, and its effects on the human Kv1.5 (hKv1.5) currents were recorded in mouse fi broblasts (Ltk^- cells) by whole-cell patch-clamp technique. Decursin inhibited hKv1.5 current in a concentration-dependent manner, with an IC₅₀ value of 2.7 μM at +60 mV. Decursin accelerated the inactivation kinetics of the hKv1.5 channel, and slowed the deactivation kinetics of the hKv1.5 current, resulting in a tail crossover phenomenon. Also, decursin inhibited the hKv1.5 current in a use-dependent manner. These results strongly suggest that decursin is a kind of open-channel blocker of the hKv1.5 channel.

Original language	English
Pages (from-to)	33-37
Number of pages	5
Journal	Biomolecules and Therapeutics
Volume	19
Issue number	1
DOIs	https://doi.org/10.4062/biomolther.2011.19.1.033
State	Published - 2011.01

Keywords

Angelica gigas nakai
Decursin
hKv1.5 channel blocker

Quacquarelli Symonds(QS) Subject Topics

Medicine
Pharmacy & Pharmacology
Biological Sciences

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10.4062/biomolther.2011.19.1.033

Cite this

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title = "Decursin from Angelica gigas nakai blocks hkv1.5 channel",

abstract = "Decursin was purifi ed from Angelica gigas Nakai, and its effects on the human Kv1.5 (hKv1.5) currents were recorded in mouse fi broblasts (Ltk- cells) by whole-cell patch-clamp technique. Decursin inhibited hKv1.5 current in a concentration-dependent manner, with an IC50 value of 2.7 μM at +60 mV. Decursin accelerated the inactivation kinetics of the hKv1.5 channel, and slowed the deactivation kinetics of the hKv1.5 current, resulting in a tail crossover phenomenon. Also, decursin inhibited the hKv1.5 current in a use-dependent manner. These results strongly suggest that decursin is a kind of open-channel blocker of the hKv1.5 channel.",

keywords = "Angelica gigas nakai, Decursin, hKv1.5 channel blocker",

author = "Kwak, \{Yong Geun\} and Choi, \{Bok Hee\} and Kim, \{Dae Keun\} and Eun, \{Jae Soon\}",

year = "2011",

month = jan,

doi = "10.4062/biomolther.2011.19.1.033",

language = "English",

volume = "19",

pages = "33--37",

journal = "Biomolecules and Therapeutics",

issn = "1976-9148",

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}

TY - JOUR

T1 - Decursin from Angelica gigas nakai blocks hkv1.5 channel

AU - Kwak, Yong Geun

AU - Choi, Bok Hee

AU - Kim, Dae Keun

AU - Eun, Jae Soon

PY - 2011/1

Y1 - 2011/1

N2 - Decursin was purifi ed from Angelica gigas Nakai, and its effects on the human Kv1.5 (hKv1.5) currents were recorded in mouse fi broblasts (Ltk- cells) by whole-cell patch-clamp technique. Decursin inhibited hKv1.5 current in a concentration-dependent manner, with an IC50 value of 2.7 μM at +60 mV. Decursin accelerated the inactivation kinetics of the hKv1.5 channel, and slowed the deactivation kinetics of the hKv1.5 current, resulting in a tail crossover phenomenon. Also, decursin inhibited the hKv1.5 current in a use-dependent manner. These results strongly suggest that decursin is a kind of open-channel blocker of the hKv1.5 channel.

AB - Decursin was purifi ed from Angelica gigas Nakai, and its effects on the human Kv1.5 (hKv1.5) currents were recorded in mouse fi broblasts (Ltk- cells) by whole-cell patch-clamp technique. Decursin inhibited hKv1.5 current in a concentration-dependent manner, with an IC50 value of 2.7 μM at +60 mV. Decursin accelerated the inactivation kinetics of the hKv1.5 channel, and slowed the deactivation kinetics of the hKv1.5 current, resulting in a tail crossover phenomenon. Also, decursin inhibited the hKv1.5 current in a use-dependent manner. These results strongly suggest that decursin is a kind of open-channel blocker of the hKv1.5 channel.

KW - Angelica gigas nakai

KW - Decursin

KW - hKv1.5 channel blocker

UR - https://www.scopus.com/pages/publications/79851492546

U2 - 10.4062/biomolther.2011.19.1.033

DO - 10.4062/biomolther.2011.19.1.033

M3 - Journal article

AN - SCOPUS:79851492546

SN - 1976-9148

VL - 19

SP - 33

EP - 37

JO - Biomolecules and Therapeutics

JF - Biomolecules and Therapeutics

IS - 1

ER -

Decursin from Angelica gigas nakai blocks hkv1.5 channel

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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