Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp.

Soo Jin Choo; Hae Ryong Park; In Ja Ryoo; Jong Pyung Kim; Bong Sik Yun; Chang Jin Kim; Kazuo Shin-Ya; Ick Dong Yoo

doi:10.1038/ja.2005.26

Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp.

Soo Jin Choo
, Hae Ryong Park
, In Ja Ryoo
, Jong Pyung Kim
, Bong Sik Yun
, Chang Jin Kim
, Kazuo Shin-Ya
, Ick Dong Yoo^*

^*Corresponding author for this work

Environmental Biotechnology

Korea Research Institute of Bioscience and Biotechnology
Kyungnam University
The University of Tokyo

Research output: Contribution to journal › Journal article › peer-review

34 Scopus citations

Abstract

Glucose-regulated protein 78 (GRP78) resides in endoplasmic reticulum (ER) and plays a role in protecting tumor cells against the toxic effects of anticancer agents. During the search for down-regulators of GRP78 using a reporter gene (luciferase) assay system, we isolated a novel compound designated as deoxyverrucosidin (1), a congener of verrucosidin (2), from Penicillium sp. and identified it as a down-regulator of the grp78 gene. The structure of 1 was determined by mainly ESI-mass and two-dimensional NMR spectra. 1 dose-dependently inhibited the expression of GRP78 promoter with an IC ₅₀ of 30 nM.

Original language	English
Pages (from-to)	210-213
Number of pages	4
Journal	Journal of Antibiotics
Volume	58
Issue number	3
DOIs	https://doi.org/10.1038/ja.2005.26
State	Published - 2005.03

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer agents
Deoxyverrucosidin
Glucose-regulated protein 78 (GRP78)
Penicillium sp.

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10.1038/ja.2005.26

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title = "Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp.",

abstract = "Glucose-regulated protein 78 (GRP78) resides in endoplasmic reticulum (ER) and plays a role in protecting tumor cells against the toxic effects of anticancer agents. During the search for down-regulators of GRP78 using a reporter gene (luciferase) assay system, we isolated a novel compound designated as deoxyverrucosidin (1), a congener of verrucosidin (2), from Penicillium sp. and identified it as a down-regulator of the grp78 gene. The structure of 1 was determined by mainly ESI-mass and two-dimensional NMR spectra. 1 dose-dependently inhibited the expression of GRP78 promoter with an IC 50 of 30 nM.",

keywords = "Anticancer agents, Deoxyverrucosidin, Glucose-regulated protein 78 (GRP78), Penicillium sp.",

author = "Choo, \{Soo Jin\} and Park, \{Hae Ryong\} and Ryoo, \{In Ja\} and Kim, \{Jong Pyung\} and Yun, \{Bong Sik\} and Kim, \{Chang Jin\} and Kazuo Shin-Ya and Yoo, \{Ick Dong\}",

year = "2005",

month = mar,

doi = "10.1038/ja.2005.26",

language = "English",

volume = "58",

pages = "210--213",

journal = "Journal of Antibiotics",

issn = "0021-8820",

number = "3",

}

TY - JOUR

T1 - Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp.

AU - Choo, Soo Jin

AU - Park, Hae Ryong

AU - Ryoo, In Ja

AU - Kim, Jong Pyung

AU - Yun, Bong Sik

AU - Kim, Chang Jin

AU - Shin-Ya, Kazuo

AU - Yoo, Ick Dong

PY - 2005/3

Y1 - 2005/3

N2 - Glucose-regulated protein 78 (GRP78) resides in endoplasmic reticulum (ER) and plays a role in protecting tumor cells against the toxic effects of anticancer agents. During the search for down-regulators of GRP78 using a reporter gene (luciferase) assay system, we isolated a novel compound designated as deoxyverrucosidin (1), a congener of verrucosidin (2), from Penicillium sp. and identified it as a down-regulator of the grp78 gene. The structure of 1 was determined by mainly ESI-mass and two-dimensional NMR spectra. 1 dose-dependently inhibited the expression of GRP78 promoter with an IC 50 of 30 nM.

AB - Glucose-regulated protein 78 (GRP78) resides in endoplasmic reticulum (ER) and plays a role in protecting tumor cells against the toxic effects of anticancer agents. During the search for down-regulators of GRP78 using a reporter gene (luciferase) assay system, we isolated a novel compound designated as deoxyverrucosidin (1), a congener of verrucosidin (2), from Penicillium sp. and identified it as a down-regulator of the grp78 gene. The structure of 1 was determined by mainly ESI-mass and two-dimensional NMR spectra. 1 dose-dependently inhibited the expression of GRP78 promoter with an IC 50 of 30 nM.

KW - Anticancer agents

KW - Deoxyverrucosidin

KW - Glucose-regulated protein 78 (GRP78)

KW - Penicillium sp.

UR - https://www.scopus.com/pages/publications/17044421363

U2 - 10.1038/ja.2005.26

DO - 10.1038/ja.2005.26

M3 - Journal article

C2 - 15895531

AN - SCOPUS:17044421363

SN - 0021-8820

VL - 58

SP - 210

EP - 213

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 3

ER -

Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp.

Abstract

UN SDGs

Keywords

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