Design and application of a smart nanodevice by combining cationic drug delivery and hyperthermia for cancer apoptosis

Arathyram Ramachandra Kurup Sasikala; Afeesh Rajan Unnithan; Chan Hee Park; Cheol Sang Kim

doi:10.1039/c5tb02011e

Design and application of a smart nanodevice by combining cationic drug delivery and hyperthermia for cancer apoptosis

Arathyram Ramachandra Kurup Sasikala
, Afeesh Rajan Unnithan^*
, Chan Hee Park
, Cheol Sang Kim

^*Corresponding author for this work

Nano-Bio Mechanical System Engineering

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

11 Scopus citations

Abstract

Multifunctional magnetic nanoparticles have gained ample attention in the field of nanomedicine in recent years. Here, novel superparamagnetic core-shell manganese ferrite nanoparticles (MFNP)-encapsulated mesoporous silica nanoparticles (MSMFNPs) loaded with anticancer drug doxorubicin (DOX) for the combined application of hyperthermia and chemotherapy were developed and tested in vitro. Our results indicate that DOX-MSMFNPs achieved a favorable hyperthermic response in an alternating magnetic field in addition to cancer cell-specific cationic DOX release due to the cleavage of amide bonds under acidic pH, and synergistically contributed towards an enhanced tumoricidal effect.

Original language	English
Pages (from-to)	785-792
Number of pages	8
Journal	Journal of Materials Chemistry B
Volume	4
Issue number	4
DOIs	https://doi.org/10.1039/c5tb02011e
State	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Quacquarelli Symonds(QS) Subject Topics

Materials Science
Chemistry
Biological Sciences

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10.1039/c5tb02011e

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title = "Design and application of a smart nanodevice by combining cationic drug delivery and hyperthermia for cancer apoptosis",

abstract = "Multifunctional magnetic nanoparticles have gained ample attention in the field of nanomedicine in recent years. Here, novel superparamagnetic core-shell manganese ferrite nanoparticles (MFNP)-encapsulated mesoporous silica nanoparticles (MSMFNPs) loaded with anticancer drug doxorubicin (DOX) for the combined application of hyperthermia and chemotherapy were developed and tested in vitro. Our results indicate that DOX-MSMFNPs achieved a favorable hyperthermic response in an alternating magnetic field in addition to cancer cell-specific cationic DOX release due to the cleavage of amide bonds under acidic pH, and synergistically contributed towards an enhanced tumoricidal effect.",

author = "\{Ramachandra Kurup Sasikala\}, Arathyram and Unnithan, \{Afeesh Rajan\} and Park, \{Chan Hee\} and Kim, \{Cheol Sang\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c5tb02011e",

language = "English",

volume = "4",

pages = "785--792",

journal = "Journal of Materials Chemistry B",

issn = "2050-7518",

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TY - JOUR

T1 - Design and application of a smart nanodevice by combining cationic drug delivery and hyperthermia for cancer apoptosis

AU - Ramachandra Kurup Sasikala, Arathyram

AU - Unnithan, Afeesh Rajan

AU - Park, Chan Hee

AU - Kim, Cheol Sang

PY - 2016

Y1 - 2016

N2 - Multifunctional magnetic nanoparticles have gained ample attention in the field of nanomedicine in recent years. Here, novel superparamagnetic core-shell manganese ferrite nanoparticles (MFNP)-encapsulated mesoporous silica nanoparticles (MSMFNPs) loaded with anticancer drug doxorubicin (DOX) for the combined application of hyperthermia and chemotherapy were developed and tested in vitro. Our results indicate that DOX-MSMFNPs achieved a favorable hyperthermic response in an alternating magnetic field in addition to cancer cell-specific cationic DOX release due to the cleavage of amide bonds under acidic pH, and synergistically contributed towards an enhanced tumoricidal effect.

AB - Multifunctional magnetic nanoparticles have gained ample attention in the field of nanomedicine in recent years. Here, novel superparamagnetic core-shell manganese ferrite nanoparticles (MFNP)-encapsulated mesoporous silica nanoparticles (MSMFNPs) loaded with anticancer drug doxorubicin (DOX) for the combined application of hyperthermia and chemotherapy were developed and tested in vitro. Our results indicate that DOX-MSMFNPs achieved a favorable hyperthermic response in an alternating magnetic field in addition to cancer cell-specific cationic DOX release due to the cleavage of amide bonds under acidic pH, and synergistically contributed towards an enhanced tumoricidal effect.

UR - https://www.scopus.com/pages/publications/84955502036

U2 - 10.1039/c5tb02011e

DO - 10.1039/c5tb02011e

M3 - Journal article

AN - SCOPUS:84955502036

SN - 2050-7518

VL - 4

SP - 785

EP - 792

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 4

ER -

Design and application of a smart nanodevice by combining cationic drug delivery and hyperthermia for cancer apoptosis

Abstract

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