Desmethylanhydroicaritin isolated from Sophora flavescens, shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion

Chang Won Kang; Nan Hee Kim; Huyn Ah Jung; Hyung Wook Choi; Min Jae Kang; Jae Sue Choi; Gun Do Kim

doi:10.1016/j.etap.2016.03.003

Desmethylanhydroicaritin isolated from Sophora flavescens, shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion

Chang Won Kang
, Nan Hee Kim
, Huyn Ah Jung
, Hyung Wook Choi
, Min Jae Kang
, Jae Sue Choi^*
, Gun Do Kim

^*Corresponding author for this work

Department of Food Science and Human Nutrition

Pukyong National University

Research output: Contribution to journal › Journal article › peer-review

13 Scopus citations

Abstract

This study is the first report of the antitumor activities of desmethylanhydroicaritin (DMAI) isolated from Sophora flavescens on U87MG cells. Human glioblastoma is one of the most aggressive malignant type of brain tumors and highly diffuses to around normal brain tissues. DMAI showed anti-proliferation effects on U87MG cells at the concentration of 30 μM, however did not affect to HEK-293 cells. DMAI induced anti-proliferation effects via ERK/MAPK, PI3 K/Akt/mTOR signal pathway and G2/M phase cell cycle arrest. DMAI led to morphological change and inhibition of filapodia formation through regulation of Rac 1 and Cdc 42. In addition, migration and invasion of U87MG cells were inhibited by DMAI via down-regulation of matrix metalloproteinase (MMP) -2 and MMP -9 expressions and activities. Our results suggest that DMAI has a potential as a therapeutic agent against glioblastoma cells.

Original language	English
Pages (from-to)	140-148
Number of pages	9
Journal	Environmental Toxicology and Pharmacology
Volume	43
DOIs	https://doi.org/10.1016/j.etap.2016.03.003
State	Published - 2016.04.1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Desmethylanhydroicaritin
Invasion
Migration
Mitogen-activated protein kinase
Proliferation
U87MG

Quacquarelli Symonds(QS) Subject Topics

Environmental Sciences
Pharmacy & Pharmacology

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10.1016/j.etap.2016.03.003

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@article{213f83734004430f85e15f0caf2ddb4f,

title = "Desmethylanhydroicaritin isolated from Sophora flavescens, shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion",

abstract = "This study is the first report of the antitumor activities of desmethylanhydroicaritin (DMAI) isolated from Sophora flavescens on U87MG cells. Human glioblastoma is one of the most aggressive malignant type of brain tumors and highly diffuses to around normal brain tissues. DMAI showed anti-proliferation effects on U87MG cells at the concentration of 30 μM, however did not affect to HEK-293 cells. DMAI induced anti-proliferation effects via ERK/MAPK, PI3 K/Akt/mTOR signal pathway and G2/M phase cell cycle arrest. DMAI led to morphological change and inhibition of filapodia formation through regulation of Rac 1 and Cdc 42. In addition, migration and invasion of U87MG cells were inhibited by DMAI via down-regulation of matrix metalloproteinase (MMP) -2 and MMP -9 expressions and activities. Our results suggest that DMAI has a potential as a therapeutic agent against glioblastoma cells.",

keywords = "Desmethylanhydroicaritin, Invasion, Migration, Mitogen-activated protein kinase, Proliferation, U87MG",

author = "Kang, \{Chang Won\} and Kim, \{Nan Hee\} and Jung, \{Huyn Ah\} and Choi, \{Hyung Wook\} and Kang, \{Min Jae\} and Choi, \{Jae Sue\} and Kim, \{Gun Do\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

year = "2016",

month = apr,

day = "1",

doi = "10.1016/j.etap.2016.03.003",

language = "English",

volume = "43",

pages = "140--148",

journal = "Environmental Toxicology and Pharmacology",

issn = "1382-6689",

}

TY - JOUR

T1 - Desmethylanhydroicaritin isolated from Sophora flavescens, shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion

AU - Kang, Chang Won

AU - Kim, Nan Hee

AU - Jung, Huyn Ah

AU - Choi, Hyung Wook

AU - Kang, Min Jae

AU - Choi, Jae Sue

AU - Kim, Gun Do

PY - 2016/4/1

Y1 - 2016/4/1

N2 - This study is the first report of the antitumor activities of desmethylanhydroicaritin (DMAI) isolated from Sophora flavescens on U87MG cells. Human glioblastoma is one of the most aggressive malignant type of brain tumors and highly diffuses to around normal brain tissues. DMAI showed anti-proliferation effects on U87MG cells at the concentration of 30 μM, however did not affect to HEK-293 cells. DMAI induced anti-proliferation effects via ERK/MAPK, PI3 K/Akt/mTOR signal pathway and G2/M phase cell cycle arrest. DMAI led to morphological change and inhibition of filapodia formation through regulation of Rac 1 and Cdc 42. In addition, migration and invasion of U87MG cells were inhibited by DMAI via down-regulation of matrix metalloproteinase (MMP) -2 and MMP -9 expressions and activities. Our results suggest that DMAI has a potential as a therapeutic agent against glioblastoma cells.

AB - This study is the first report of the antitumor activities of desmethylanhydroicaritin (DMAI) isolated from Sophora flavescens on U87MG cells. Human glioblastoma is one of the most aggressive malignant type of brain tumors and highly diffuses to around normal brain tissues. DMAI showed anti-proliferation effects on U87MG cells at the concentration of 30 μM, however did not affect to HEK-293 cells. DMAI induced anti-proliferation effects via ERK/MAPK, PI3 K/Akt/mTOR signal pathway and G2/M phase cell cycle arrest. DMAI led to morphological change and inhibition of filapodia formation through regulation of Rac 1 and Cdc 42. In addition, migration and invasion of U87MG cells were inhibited by DMAI via down-regulation of matrix metalloproteinase (MMP) -2 and MMP -9 expressions and activities. Our results suggest that DMAI has a potential as a therapeutic agent against glioblastoma cells.

KW - Desmethylanhydroicaritin

KW - Invasion

KW - Migration

KW - Mitogen-activated protein kinase

KW - Proliferation

KW - U87MG

UR - https://www.scopus.com/pages/publications/84960920975

U2 - 10.1016/j.etap.2016.03.003

DO - 10.1016/j.etap.2016.03.003

M3 - Journal article

C2 - 26991848

AN - SCOPUS:84960920975

SN - 1382-6689

VL - 43

SP - 140

EP - 148

JO - Environmental Toxicology and Pharmacology

JF - Environmental Toxicology and Pharmacology

ER -

Desmethylanhydroicaritin isolated from Sophora flavescens, shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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