Dissolution properties of lercanidipine solid dispersion manufactured water - Soluble polymer PVP K-30

Hyun Ki Jeong; Jin Young Park; Su Young Kim; Se Rom Cha; Seon Eui Lee; Na Keum Jang; Won Taek Lee; Jin Pyo Lee; Jeong Eun Song; Gilson Khang

doi:10.7317/pk.2016.40.1.33

Dissolution properties of lercanidipine solid dispersion manufactured water - Soluble polymer PVP K-30

Hyun Ki Jeong
, Jin Young Park
, Su Young Kim
, Se Rom Cha
, Seon Eui Lee
, Na Keum Jang
, Won Taek Lee
, Jin Pyo Lee
, Jeong Eun Song
, Gilson Khang^*

^*Corresponding author for this work

Department of Polymer -Nano Science &Technology

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

3 Scopus citations

Abstract

Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine, which opens the blood vessels for allowing the blood to circulate more freely around the body. Lercanidipine is a poorly water soluble drug and quite difficult to deliver. Taking this into account, in the study, we have designed lercanidipine loaded water soluble polymer PVP K-30 via solid dispersion method using spray drying and rotary evaporation to improve the dissolution properties. Further, the dissolution behavior of the materials were evaluated by in vitro assays. Results showed that solid dispersion has increased the dissolution properties of the materials owing to the change in the drug chemical structure.

Original language	English
Pages (from-to)	33-41
Number of pages	9
Journal	Polymer (Korea)
Volume	40
Issue number	1
DOIs	https://doi.org/10.7317/pk.2016.40.1.33
State	Published - 2016.01

Keywords

Lercanidipine
PVP K30
Rotary evaporation
Solid dispersion
Spray drying

Quacquarelli Symonds(QS) Subject Topics

Materials Science
Engineering - Chemical

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10.7317/pk.2016.40.1.33

Cite this

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title = "Dissolution properties of lercanidipine solid dispersion manufactured water - Soluble polymer PVP K-30",

abstract = "Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine, which opens the blood vessels for allowing the blood to circulate more freely around the body. Lercanidipine is a poorly water soluble drug and quite difficult to deliver. Taking this into account, in the study, we have designed lercanidipine loaded water soluble polymer PVP K-30 via solid dispersion method using spray drying and rotary evaporation to improve the dissolution properties. Further, the dissolution behavior of the materials were evaluated by in vitro assays. Results showed that solid dispersion has increased the dissolution properties of the materials owing to the change in the drug chemical structure.",

keywords = "Lercanidipine, PVP K30, Rotary evaporation, Solid dispersion, Spray drying",

author = "Jeong, \{Hyun Ki\} and Park, \{Jin Young\} and Kim, \{Su Young\} and Cha, \{Se Rom\} and Lee, \{Seon Eui\} and Jang, \{Na Keum\} and Lee, \{Won Taek\} and Lee, \{Jin Pyo\} and Song, \{Jeong Eun\} and Gilson Khang",

year = "2016",

month = jan,

doi = "10.7317/pk.2016.40.1.33",

language = "English",

volume = "40",

pages = "33--41",

journal = "Polymer (Korea)",

issn = "0379-153X",

number = "1",

}

TY - JOUR

T1 - Dissolution properties of lercanidipine solid dispersion manufactured water - Soluble polymer PVP K-30

AU - Jeong, Hyun Ki

AU - Park, Jin Young

AU - Kim, Su Young

AU - Cha, Se Rom

AU - Lee, Seon Eui

AU - Jang, Na Keum

AU - Lee, Won Taek

AU - Lee, Jin Pyo

AU - Song, Jeong Eun

AU - Khang, Gilson

PY - 2016/1

Y1 - 2016/1

N2 - Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine, which opens the blood vessels for allowing the blood to circulate more freely around the body. Lercanidipine is a poorly water soluble drug and quite difficult to deliver. Taking this into account, in the study, we have designed lercanidipine loaded water soluble polymer PVP K-30 via solid dispersion method using spray drying and rotary evaporation to improve the dissolution properties. Further, the dissolution behavior of the materials were evaluated by in vitro assays. Results showed that solid dispersion has increased the dissolution properties of the materials owing to the change in the drug chemical structure.

AB - Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine, which opens the blood vessels for allowing the blood to circulate more freely around the body. Lercanidipine is a poorly water soluble drug and quite difficult to deliver. Taking this into account, in the study, we have designed lercanidipine loaded water soluble polymer PVP K-30 via solid dispersion method using spray drying and rotary evaporation to improve the dissolution properties. Further, the dissolution behavior of the materials were evaluated by in vitro assays. Results showed that solid dispersion has increased the dissolution properties of the materials owing to the change in the drug chemical structure.

KW - Lercanidipine

KW - PVP K30

KW - Rotary evaporation

KW - Solid dispersion

KW - Spray drying

UR - https://www.scopus.com/pages/publications/84960895573

U2 - 10.7317/pk.2016.40.1.33

DO - 10.7317/pk.2016.40.1.33

M3 - Journal article

AN - SCOPUS:84960895573

SN - 0379-153X

VL - 40

SP - 33

EP - 41

JO - Polymer (Korea)

JF - Polymer (Korea)

IS - 1

ER -

Dissolution properties of lercanidipine solid dispersion manufactured water - Soluble polymer PVP K-30

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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