DNA methylation and hydroxymethylation in hematologic differentiation and transformation

Myunggon Ko; Jungeun An; Anjana Rao

doi:10.1016/j.ceb.2015.10.009

DNA methylation and hydroxymethylation in hematologic differentiation and transformation

Myunggon Ko^*
, Jungeun An
, Anjana Rao

^*Corresponding author for this work

Department of Biological Sciences

Ulsan National Institute of Science and Technology
La Jolla Institute for Allergy and Immunology
University of California at San Diego
Sanford Consortium for Regenerative Medicine

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

Maintenance of the balance of DNA methylation and demethylation is fundamental for normal cellular development and function. Members of the Ten-Eleven-Translocation (TET) family proteins are Fe(II)-dependent and 2-oxoglutarate-dependent dioxygenases that catalyze sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and subsequent oxidized derivatives in DNA. In addition to their roles as intermediates in DNA demethylation, these oxidized methylcytosines are novel epigenetic modifications of DNA. DNA methylation and hydroxymethylation profiles are markedly disrupted in a wide range of cancers but how these changes are related to the pathogenesis of cancers is still ambiguous. In this review, we discuss the current understanding of TET protein functions in normal and malignant hematopoietic development and the ongoing questions to be resolved.

Original language	English
Pages (from-to)	91-101
Number of pages	11
Journal	Current Opinion in Cell Biology
Volume	37
DOIs	https://doi.org/10.1016/j.ceb.2015.10.009
State	Published - 2015.12.1

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title = "DNA methylation and hydroxymethylation in hematologic differentiation and transformation",

abstract = "Maintenance of the balance of DNA methylation and demethylation is fundamental for normal cellular development and function. Members of the Ten-Eleven-Translocation (TET) family proteins are Fe(II)-dependent and 2-oxoglutarate-dependent dioxygenases that catalyze sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and subsequent oxidized derivatives in DNA. In addition to their roles as intermediates in DNA demethylation, these oxidized methylcytosines are novel epigenetic modifications of DNA. DNA methylation and hydroxymethylation profiles are markedly disrupted in a wide range of cancers but how these changes are related to the pathogenesis of cancers is still ambiguous. In this review, we discuss the current understanding of TET protein functions in normal and malignant hematopoietic development and the ongoing questions to be resolved.",

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T1 - DNA methylation and hydroxymethylation in hematologic differentiation and transformation

AU - Ko, Myunggon

AU - An, Jungeun

AU - Rao, Anjana

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N2 - Maintenance of the balance of DNA methylation and demethylation is fundamental for normal cellular development and function. Members of the Ten-Eleven-Translocation (TET) family proteins are Fe(II)-dependent and 2-oxoglutarate-dependent dioxygenases that catalyze sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and subsequent oxidized derivatives in DNA. In addition to their roles as intermediates in DNA demethylation, these oxidized methylcytosines are novel epigenetic modifications of DNA. DNA methylation and hydroxymethylation profiles are markedly disrupted in a wide range of cancers but how these changes are related to the pathogenesis of cancers is still ambiguous. In this review, we discuss the current understanding of TET protein functions in normal and malignant hematopoietic development and the ongoing questions to be resolved.

AB - Maintenance of the balance of DNA methylation and demethylation is fundamental for normal cellular development and function. Members of the Ten-Eleven-Translocation (TET) family proteins are Fe(II)-dependent and 2-oxoglutarate-dependent dioxygenases that catalyze sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and subsequent oxidized derivatives in DNA. In addition to their roles as intermediates in DNA demethylation, these oxidized methylcytosines are novel epigenetic modifications of DNA. DNA methylation and hydroxymethylation profiles are markedly disrupted in a wide range of cancers but how these changes are related to the pathogenesis of cancers is still ambiguous. In this review, we discuss the current understanding of TET protein functions in normal and malignant hematopoietic development and the ongoing questions to be resolved.

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DO - 10.1016/j.ceb.2015.10.009

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VL - 37

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JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

ER -

DNA methylation and hydroxymethylation in hematologic differentiation and transformation

Abstract

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