Effect of chitosan oligosaccharide on non-specific immune parameters in catfish (Silurus asotus)

We examined the effects of a single intraperitoneal injection of four different concentrations (0, 50, 100, 150, 200 mg/kg) of chitosan oligosaccharide on superoxide anion, plasma lysozyme and anti-protease in catfish (Silurus asotus). The groups injected with 100 and 150 mg/kg chitosan had significantly enhanced superoxide anion levels in leukocytes, plasma lysozyme and anti-protease compared to the mock-injected group (0 mg/kg). Based on these results, chitosan oligosaccharide is thought to stimulate and/or modulate the non-specific immune response in catfish.