Abstract
To evaluate the effects of combined therapy of anti-tubercular agents with theophylline during treatment of concurrent pulmonary tuberculosis and chronic obstructive pulmonary disease or asthma, the clearance and half life of theophylline was estimated in a control group not treated with anti-tubercular agents, a group treated with isoniazid (INH), rifampicin (RMP), ethambutol (EMB) and pyrazinamide (PZA), and a group treated with INH, RMP and EMB. Clearances of theophylline in the treated groups were significantly lower than in the control group, and the half-life of theophylline was longer than in the control. These results suggest that patients administered combinations of anti-tubercular agents with theophylline require lower doses of theophylline.
| Original language | English |
|---|---|
| Pages (from-to) | 784-787 |
| Number of pages | 4 |
| Journal | International Journal of Tuberculosis and Lung Disease |
| Volume | 4 |
| Issue number | 8 |
| State | Published - 2000 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Anti-tubercular agents
- Theophylline pharmacokinetics
Quacquarelli Symonds(QS) Subject Topics
- Medicine
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