Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats

Tae Yong Shin; Hyun Ja Jeong; Sug Min Jun; Han Jung Chae; Hyung Ryong Kim; Seung Hwa Baek; Hyung Min Kim

doi:10.3109/08923979909007136

Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats

Tae Yong Shin^*
, Hyun Ja Jeong
, Sug Min Jun
, Han Jung Chae
, Hyung Ryong Kim
, Seung Hwa Baek
, Hyung Min Kim

^*Corresponding author for this work

Woosuk University
Wonkwang University

Research output: Contribution to journal › Journal article › peer-review

26 Scopus citations

Abstract

We investigated the effect of an aqueous extract of Schizonepeta tenuifolia (STAE) on mast cell-mediated immediate-type hypersensitivity. STAE inhibited systemic allergic reaction induced by compound 48/80 in rats dose- dependently. STAE also inhibited plasma histamine levels induced by compound 48/80. STAE inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. In addition, STAE does-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. However, STAE had a significant enhancing effect on anti-DNP IgE-induced tumor necrosis factor-α (TNF-α) production from RPMC. These results indicate that STAE inhibits immediate-type hypersensitivity and suggest that STAE can selectively activate the TNF-α production from RPMC.

Original language	English
Pages (from-to)	705-715
Number of pages	11
Journal	Immunopharmacology and Immunotoxicology
Volume	21
Issue number	4
DOIs	https://doi.org/10.3109/08923979909007136
State	Published - 1999

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title = "Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats",

abstract = "We investigated the effect of an aqueous extract of Schizonepeta tenuifolia (STAE) on mast cell-mediated immediate-type hypersensitivity. STAE inhibited systemic allergic reaction induced by compound 48/80 in rats dose- dependently. STAE also inhibited plasma histamine levels induced by compound 48/80. STAE inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. In addition, STAE does-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. However, STAE had a significant enhancing effect on anti-DNP IgE-induced tumor necrosis factor-α (TNF-α) production from RPMC. These results indicate that STAE inhibits immediate-type hypersensitivity and suggest that STAE can selectively activate the TNF-α production from RPMC.",

author = "Shin, \{Tae Yong\} and Jeong, \{Hyun Ja\} and Jun, \{Sug Min\} and Chae, \{Han Jung\} and Kim, \{Hyung Ryong\} and Baek, \{Seung Hwa\} and Kim, \{Hyung Min\}",

year = "1999",

doi = "10.3109/08923979909007136",

language = "English",

volume = "21",

pages = "705--715",

journal = "Immunopharmacology and Immunotoxicology",

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TY - JOUR

T1 - Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats

AU - Shin, Tae Yong

AU - Jeong, Hyun Ja

AU - Jun, Sug Min

AU - Chae, Han Jung

AU - Kim, Hyung Ryong

AU - Baek, Seung Hwa

AU - Kim, Hyung Min

PY - 1999

Y1 - 1999

N2 - We investigated the effect of an aqueous extract of Schizonepeta tenuifolia (STAE) on mast cell-mediated immediate-type hypersensitivity. STAE inhibited systemic allergic reaction induced by compound 48/80 in rats dose- dependently. STAE also inhibited plasma histamine levels induced by compound 48/80. STAE inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. In addition, STAE does-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. However, STAE had a significant enhancing effect on anti-DNP IgE-induced tumor necrosis factor-α (TNF-α) production from RPMC. These results indicate that STAE inhibits immediate-type hypersensitivity and suggest that STAE can selectively activate the TNF-α production from RPMC.

AB - We investigated the effect of an aqueous extract of Schizonepeta tenuifolia (STAE) on mast cell-mediated immediate-type hypersensitivity. STAE inhibited systemic allergic reaction induced by compound 48/80 in rats dose- dependently. STAE also inhibited plasma histamine levels induced by compound 48/80. STAE inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. In addition, STAE does-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. However, STAE had a significant enhancing effect on anti-DNP IgE-induced tumor necrosis factor-α (TNF-α) production from RPMC. These results indicate that STAE inhibits immediate-type hypersensitivity and suggest that STAE can selectively activate the TNF-α production from RPMC.

UR - https://www.scopus.com/pages/publications/0032710080

U2 - 10.3109/08923979909007136

DO - 10.3109/08923979909007136

M3 - Journal article

C2 - 10584206

AN - SCOPUS:0032710080

SN - 0892-3973

VL - 21

SP - 705

EP - 715

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

IS - 4

ER -

Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats

Abstract

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