Effect of the MeOH extract of adventious root culture of Panax ginseng on hyperlipidemic rat induced by high fat-rich diet

We have investigated the effect of MeOH extract of the adventious root culture of Panax ginseng on hyperlipidemic rats induced by fat-rich diet. We also analyzed and compared the content ginsenosides of the cultured ginsengs by HPLC. After oral administration of the MeOH extract to hyperlipidemic rats for four weeks, the variables including body weight, cholesterol, HDL, LDL, and triglyceride levels in serum were measured. One of the cultured ginseng roots (CBN3) decreased cholesterol and LDL-cholesterol and increased HDL-cholesterol levels in serum. HPLC analysis demonstrated that CBN3 contains more Rb₁ and Rd ginsenosides than any other cultured ginsengs and cultivated ginseng. These results sugest that CBN3 with high contents of Rb₁ and Rd may be useful in lowering blood cholesterol.