Effectiveness of an allograft cortical bone plate in canine fracture model

Currently, absorbable fixation materials such as ceramics, decalcified cortical bone and several synthetic absorbable polymers were used in clinic. But these absorbable materials have some disadvantage such as early absorption, low strength and a few fixation ability. In this study, the effectiveness of internal fixation with bone plate using freeze-drying allograft cortical bone(FACB) investigated in fracture model of the dogs, FACB were known to have same strength as raw bone, and function of delayed absorption and induction of new bone formation. The new bone formations in FACB plate were observed in 10 out of 12 dogs, and started from 5.7 weeks, and unioned to 13 weeks after fixation. Absorption of FACB plates were observed in all cases started from 7 w and continued to 48 w. The bone plate processing with FACB may be apply clinically by useful internal fixation materials to help healing by induction of new bone formation, and to be not requested removal of fixation material by delayed absorption.