Enhancing the anti-bacterial activity of nanofibrous polyurethane membranes by incorporating glycyrrhizic acid-conjugated β-Cyclodextrin

Licorice contains glycyrrhizic acid, an antibacterial and anti-inflammatory component widely used as an ingredient for disinfection and trauma treatment since ancient times. In this study, antibacterial capsules were prepared by conjugating glycyrrhizic acid as a natural antibacterial substance with β-cyclodextrin. In addition, after mixing it with a polymer solution, it was successfully manufactured into fibers using an electrospinning technology. Through several analyzes, it was confirmed that the antibacterial capsule was well distributed within the prepared electrospinning membrane. The antibacterial test confirmed that glycyrrhizic acid encapsulated with β-cyclodextrin maintains its antibacterial properties. If such electrospun fiber containing an antibacterial capsule is manufactured, it can be applied to trauma treatment such as wound dressing due to its antibacterial effect. In addition, it can be used in various fields such as infection prevention and disease treatment by utilizing the anti-inflammatory and antiviral effects of glycyrrhizic acid.