Epstein-Barr virus antibody level and gastric cancer risk in Korea: A nested case-control study

Y. Kim; A. Shin; J. Gwack; K. P. Ko; C. S. Kim; S. K. Park; Y. C. Hong; D. Kang; K. Y. Yoo

doi:10.1038/sj.bjc.6605146

Epstein-Barr virus antibody level and gastric cancer risk in Korea: A nested case-control study

Y. Kim
, A. Shin
, J. Gwack
, K. P. Ko
, C. S. Kim
, S. K. Park
, Y. C. Hong
, D. Kang
, K. Y. Yoo^*

^*Corresponding author for this work

Department of Medicine

National Cancer Center Korea
Seoul National University
Korea National Institute of Health

Research output: Contribution to journal › Journal article › peer-review

22 Scopus citations

Abstract

Background: Few cohort studies have investigated Epstein-Barr virus (EBV) infection before the occurrence of gastric cancer. Methods: Among 14440 cohort participants, 100 incident gastric cancer cases were individually matched to two controls. Epstein-Barr virus antibodies IgG and IgA against viral capsid antigen (VCA), EBV nuclear antigen (EBNA) antibody IgG, and early antigen (EA) antibody IgG were measured using enzyme immunoassays (EIAs).Results: The highest titres of VCA IgG (odds ratio (OR): 1.37, 95 confidence interval (CI): 0.62-3.06) or EBNA IgG (OR: 0.87, 95 CI: 0.51-1.46) were not associated with gastric cancer risk. Conclusion: Higher levels of VCA IgG or EBNA IgG were not associated with increased risk of gastric adenocarcinoma in Koreans.

Original language	English
Pages (from-to)	526-529
Number of pages	4
Journal	British Journal of Cancer
Volume	101
Issue number	3
DOIs	https://doi.org/10.1038/sj.bjc.6605146
State	Published - 2009.08.4

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Epstein?Barr virus
Korea
Nested case?control study
Stomach neoplasms

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10.1038/sj.bjc.6605146

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@article{5102a9ea18d24abbb43fb7122c3d2233,

title = "Epstein-Barr virus antibody level and gastric cancer risk in Korea: A nested case-control study",

abstract = "Background: Few cohort studies have investigated Epstein-Barr virus (EBV) infection before the occurrence of gastric cancer. Methods: Among 14440 cohort participants, 100 incident gastric cancer cases were individually matched to two controls. Epstein-Barr virus antibodies IgG and IgA against viral capsid antigen (VCA), EBV nuclear antigen (EBNA) antibody IgG, and early antigen (EA) antibody IgG were measured using enzyme immunoassays (EIAs).Results: The highest titres of VCA IgG (odds ratio (OR): 1.37, 95 confidence interval (CI): 0.62-3.06) or EBNA IgG (OR: 0.87, 95 CI: 0.51-1.46) were not associated with gastric cancer risk. Conclusion: Higher levels of VCA IgG or EBNA IgG were not associated with increased risk of gastric adenocarcinoma in Koreans.",

keywords = "Epstein?Barr virus, Korea, Nested case?control study, Stomach neoplasms",

author = "Y. Kim and A. Shin and J. Gwack and Ko, \{K. P.\} and Kim, \{C. S.\} and Park, \{S. K.\} and Hong, \{Y. C.\} and D. Kang and Yoo, \{K. Y.\}",

year = "2009",

month = aug,

day = "4",

doi = "10.1038/sj.bjc.6605146",

language = "English",

volume = "101",

pages = "526--529",

journal = "British Journal of Cancer",

issn = "0007-0920",

number = "3",

}

TY - JOUR

T1 - Epstein-Barr virus antibody level and gastric cancer risk in Korea

T2 - A nested case-control study

AU - Kim, Y.

AU - Shin, A.

AU - Gwack, J.

AU - Ko, K. P.

AU - Kim, C. S.

AU - Park, S. K.

AU - Hong, Y. C.

AU - Kang, D.

AU - Yoo, K. Y.

PY - 2009/8/4

Y1 - 2009/8/4

N2 - Background: Few cohort studies have investigated Epstein-Barr virus (EBV) infection before the occurrence of gastric cancer. Methods: Among 14440 cohort participants, 100 incident gastric cancer cases were individually matched to two controls. Epstein-Barr virus antibodies IgG and IgA against viral capsid antigen (VCA), EBV nuclear antigen (EBNA) antibody IgG, and early antigen (EA) antibody IgG were measured using enzyme immunoassays (EIAs).Results: The highest titres of VCA IgG (odds ratio (OR): 1.37, 95 confidence interval (CI): 0.62-3.06) or EBNA IgG (OR: 0.87, 95 CI: 0.51-1.46) were not associated with gastric cancer risk. Conclusion: Higher levels of VCA IgG or EBNA IgG were not associated with increased risk of gastric adenocarcinoma in Koreans.

AB - Background: Few cohort studies have investigated Epstein-Barr virus (EBV) infection before the occurrence of gastric cancer. Methods: Among 14440 cohort participants, 100 incident gastric cancer cases were individually matched to two controls. Epstein-Barr virus antibodies IgG and IgA against viral capsid antigen (VCA), EBV nuclear antigen (EBNA) antibody IgG, and early antigen (EA) antibody IgG were measured using enzyme immunoassays (EIAs).Results: The highest titres of VCA IgG (odds ratio (OR): 1.37, 95 confidence interval (CI): 0.62-3.06) or EBNA IgG (OR: 0.87, 95 CI: 0.51-1.46) were not associated with gastric cancer risk. Conclusion: Higher levels of VCA IgG or EBNA IgG were not associated with increased risk of gastric adenocarcinoma in Koreans.

KW - Epstein?Barr virus

KW - Korea

KW - Nested case?control study

KW - Stomach neoplasms

UR - https://www.scopus.com/pages/publications/68149157507

U2 - 10.1038/sj.bjc.6605146

DO - 10.1038/sj.bjc.6605146

M3 - Journal article

C2 - 19550421

AN - SCOPUS:68149157507

SN - 0007-0920

VL - 101

SP - 526

EP - 529

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 3

ER -

Epstein-Barr virus antibody level and gastric cancer risk in Korea: A nested case-control study

Abstract

UN SDGs

Keywords

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