Abstract
We investigated the anti-inflammatory effects of ethyl pyruvate (EP) on LPS-stimulated canine PBMCs in vitro. We found that EP treatment inhibited the mRNA expressions of proinflammatory cytokines (TNF-α and IL-6), but induced mRNA expression of anti-inflammatory cytokines (IL-10). ELISA measurements revealed that EP also effectively downregulates the LPS-induced increase in proinflammatory cytokine release, while upregulating anti-inflammatory cytokine release. These data indicate that EP could be an effective anti-inflammatory agent in dogs.
| Original language | English |
|---|---|
| Pages (from-to) | 1379-1381 |
| Number of pages | 3 |
| Journal | Journal of Veterinary Medical Science |
| Volume | 72 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2010.10 |
Keywords
- Canine peripheral blood mononuclear cells
- Cytokine
- Ethyl pyruvate
- mRNA
Quacquarelli Symonds(QS) Subject Topics
- Veterinary Science
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