Evaluation of osteogenesis on duck's feet derived collagen and demineralized bone particles sponges

  • Jae Geun Cha
  • , Se Rom Cha
  • , Dae Hoon Lee
  • , Jae Hun Shin
  • , Jeong Eun Song
  • , Dong Sam Suh
  • , Chan Hum Park
  • , Gilson Khang*
  • *Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

Abstract

In this study, duck's feet derived collagen (DC) and demineralized bone particles (DBP) sponges were prepared by mixing both the components on the ratio of 3:1, 1:1, and 1:3. The physio-chemical properties of the sponges were examined by measuring compressive strength, porosity, SEM, etc. In vitro biological characterizations such as cell attachment, proliferation and osteogenic differentiation of the as-prepared sponges were studied by inoculating the bone marrow-derived stem cells (BMSC) in ratio-specific DC/DBP sponges followed by SEM, MTT, ALP, RT-PCR & histological analysis by staining. We found that the 1:1 DC/DBP sponges displayed superior osteogenesis, thus can be envisioned as a potential, biomaterial for regeneration of bone.

Original languageEnglish
Pages (from-to)858-864
Number of pages7
JournalPolymer (Korea)
Volume40
Issue number6
DOIs
StatePublished - 2016.11

Keywords

  • Bone marrow stem cells (BMSc) osteogenesis
  • Demineralized bone particle (DBP)
  • Duck's feet derived collagen (DC)

Quacquarelli Symonds(QS) Subject Topics

  • Materials Science
  • Engineering - Chemical

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